Journal of Knowledge & Health1735-577X13420190311Study of the possible effects of the biologically produced gold nanoparticles by Bacillus cereus on the function and structure of the rat`s liver31010.22100/jkh.v13i4.2051FABehrooz0000-0002-6495-2911Yahyaei 1,21- Department of Basic Sciences, Faculty of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran 2- Biological Nanoparticles in Medicine Research center, Shahrood Branch, Islamic Azad University, Shahrood, Iran. behroozyahyaei@yahoo.comParastooPourali 1,2SaharBakherad 1,2201810112019020320190128Introduction: Due to the importance of using nanoparticles in the diseases treatment and diagnosing, it is important to obtain nanoparticles that are more compatible with the body. Because, the biological synthesis of gold nanoparticles is new and novel filed, there is little information on the pharmacokinetics and pharmacodynamics of these particles. Therefore, the present study was conducted to evaluate the possible effects of biological nanoparticles on rat liver. Methods: The nanoparticles were examined on 15 male Wistar rats. For this purpose, the rats were first divided into 3 groups and after two stages of injection of the nanoparticles by intraperitoneal method, their liver was studied by optical microscope. Blood samples from rats collected for biochemical studies. Results: According to the results of the study, in both groups receiving toxic and non-toxic nanoparticles, hepatocyte cells had varicose veins. Additionally, in the recipient group, the doses of sinusoid have a slight distension and hyperemia.  Conclusion: Nanoparticles of biological gold have a low toxicity effect on liver tissue in dose dependent manner.