Journal of Knowledge & Health1735-577X14220190925Effects of Biological Nanoparticles of Silver Produced by Fusarium Fungus with Two Types of Pre-Conditioning on Morphological Changes in Brain Tissue of Male Wistar Rats2257225710.22100/jkh.v14i2.2257FAAfroozMottahedi11- Dept. of Exercise Physiology, Faculty of Basic Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran.. info@drziaa.comSayyed-JavadZiaolhagh2201906182019082620190819Introduction: Today, the production of biological nanoparticles has expanded significantly in different industries. Although their side effects have not yet been fully evaluated on brain tissue. In addition, by applying a stressor stimulus less than the threshold for injury to the tissue (pre-preparation), such as physical activity, it can increase the resistance of the tissue to more powerful stimuli. Therefore, the purpose of this study was to investigate the effect of high dose doses of biological nanoparticles with two different types of training prediction on structural changes in brain tissue of male Wistar rats.Methods: A total of 30 male Wistar rats were divided into 6 groups including healthy control, silver biological nanoparticles, aerobic exercise protocols, training protocols 2 (anaerobes), biological biological nanoparticles + exercise protocols 1, biological nanoparticles Silver + Practice Protocol 2 was done. Intraperitoneal injection of silver nanoparticles after 10 weeks of aerobic and anaerobic treatments was performed on 10% of body weight of each rat in 5 times. After 48 hours after the last injection, rats were indifferent and sample was taken. The specimens were then photographed and stained with Hematoxylin-Eosin stained with optical microscopy.Results: The results of this study showed that aerobic training and anaerobic exercise training had a significant effect on the distance traveled in the progressive endurance test on rodent treadmill (P=0.000) and body weight (P=0.000). Intraperitoneal injection of high-dose silver nanoparticles also caused inflammation and mild inflammation of brain tissue in untreated rats, and the white matter and gray matter of nerve cells did not change. On the other hand, it was reduced trained groups and in the aerobic training group it was more significant than anaerobic.Conclusion: Pre-conditioning of aerobic training can be effective in reducing the degree of brain tissue damage caused by the injection of silver biologic nanoparticles.