Journal of Knowledge & Health in Basic Medical Sciences1735-577X14420200317The Effect of Eight Weeks of Continuous Aerobic Exercise on Some Markers of Angiogenesis in Elderly Male Rats404710.22100/jkh.v14i4.2319FAGolbanoBlori11- Ph.D. Student of Sport Physiology, Islamic Azad University, Tehran, Iran.. SBLOORY@YAHOO.COMHosseinHttp://orcid.org/0000-0001-6638-1131Abednatanzi2*Hojjat AllahNikbakht3201912072020020120200126Introduction: Aging is a process in which the body's physiological capacity decreases continuously after the age of 30. One of the major changes is body mass loss (sarcopenia), which is due to decreased blood supply due to inability to exercise. The aim of this study was to investigate the effect of eight weeks of continuous aerobic exercise on some angiogenesis indices in elderly male rats.Methods: The sample of this study consisted of 20 elderly male rats that were randomly divided into control (n=10) and experimental (n=10) groups. Eighth arrives. Blood samples were obtained from the tail of adult male rats 72 hours before and after the last session of the protocol of 3 cc (VEGF), FGF, NO and Apelin 13). Independent and dependent T-test was used for analysis of data. Inter-group and intra-group evaluation was performed. Statistical analysis was performed using SPSS 16 at α=0.05.Results: Eight weeks of aerobic training significantly increased the levels of VEGF (P=0.000), NO (P=0.000), FGF (P=0.000) and Apelin 13 (P=0.000) mice. The male became older. No significant changes were observed in the control group.Conclusion: The results of this study showed that eight weeks of aerobic training significantly increased the angiogenesis levels in elderly male rats. Therefore, continuous aerobic exercise can be used as an appropriate method to increase angiogenesis in the elderly.