Shahroud University of Medical Masoume Miri journalofknowledgeandhealth@gmail.com mEDRA 202201020906 This dataset was exported with ojs2, version 3.0.0.0.

06 10.22100/jkh.v16i4.2549 https://example.com/index.php/site/article/view/2549 Abstraction Shahroud University of Medical Sciences mEDRA 01 1-69-2549 01 مجله دانش و تندرستي در علوم پایه پزشکی IR 01 1 07 23453753 JD 01 Open Journal Systems (OJS) 07 1735577 JB 16 4 دوره 16، شماره 4: 1400 06 1400 4 1 A01 Ramin Fallah Fallah, Ramin - دانشجوی دکترای فیزیولوژی ورزشی، تربیت بدنی و علوم ورزشی با گرایش فیزیولوژی، گروه تربیت بدنی و علوم ورزشی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران. 2 A01 Hassan Matin Homaee * Matin Homaee *, Hassan - دانشیار تربیت بدنی و علوم ورزشی با گرایش فیزیولوژی، گروه تربیت بدنی و علوم ورزشی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران. 3 A01 Saleh Rahmati Ahmadabad Rahmati Ahmadabad, Saleh - استادیار تربیت بدنی، گروه تربیت بدنی، واحد پردیس دانشگاه آزاد اسلامی، تهران، ایران. 01 per 01 01 Introduction: Due to the severe side effects of using or exposure to chlorpyrifos toxin (CPF) on the lungs and respiratory system, in this study, the effects of aerobic exercise on improving the effects of CPF poisoning on the level of lung tissue changes and gene expression in Rats were examined. Methods: Sixteen Wistar rats were divided into 6 groups: healthy control, dose 1-poisoned control group, dose 3- poisoned control group, dose 1-poisoned training group, dose 3-poisoned training group, and DMSO control. CPF was injected intraperitoneally in two different doses to the target groups. After intoxication, exercise was given to the target groups according to a specific exercise program. Histological assessments, evaluation of oxidative stress markers (SOD and MDA), and expression changes of Spa and Cop-1 genes in all study groups were performed. Results: Results from histological evaluations showed that the rate of mucosal destruction of lung tissue was increased in the control groups poisoned by dose 1 and dose 3 of CPF (P=0.001). SOD and MDA levels were reduced and enhanced, respectively, in poisoned control groups. After aerobic exercise, the severity of tissue damage was significantly reduced. SOD and MDA levels were significantly increased and decreased, respectively, in trained groups. At the molecular level, it was also observed that the expression of Spa and Cop-1 genes in the CPF-poisoned control group was significantly reduced, which increased significantly compared to the control groups after aerobic exercise. Conclusion: According to the results of this study, aerobic exercise seems to play an effective role in reducing tissue damage due to oxidative stress and regulating the expression of tissue-specific genes by reducing oxidative stress induced by CPF. 20211226 81 01 1-69