Knowledge & Health8420130702The Effect of Interval Training on Tumor Volume in Mice with Breast Cancer14414910.1234/knh.v8i4.42FAOmidSalehian. omid.salehian@yahoo.comRahmanSouriZoheirMohammadhasanAliasgharRavasi20130813Introduction: Exercise has effects on changing cancer factors, yet the effect of exercise on the levels of cancer factors in inflicted animals or humans has not been seriously paid attention to. Thus the aim of this study is to study the effect of aerobic continuous training on tumor volume on mice with carcinoma. Methods: In this study, 30 female balb/c mice were selected and after transplant carcinoma tumor, the mice were randomly divided into a tumor-control and interval training-tumor groups. Interval training protocol was done for 7 weeks at 20% vo2max in the first week and 75% vo2max in the last week. Blood samples were collected after protocol and Eliza method used to measure HSP70, IL4 and IFNγ. Results: The results of this study showed a decrease in the amount of Hsp70 in interval training group but the difference between the two groups was not significant (P>0.05). The results also showed a decrease in the levels of IL4 in the interval group but there was no significant difference between the groups (P>0.05). The levels of IFN in interval training group were higher than those of the control group but this difference was not significant either (P>0.05). However, tumor mass in interval training group significantly decreased (P=0.000).Conclusion: Based on the results of this research, it can be concluded that doing interval training through changing the amount of effective factors on cancer can lead to a decrease in volume mass.