Effects of green tea consumption on the biochemical, inflammatory and antioxidant parameters in patients with Coronary Artery Disease
Authors
-
Shahab Asadi1
1- Dept. of Community Nutrition, School of Nutrition and Food Science and food security research center, Isfahan University of Medical Sciences, Isfahan, Iran.
http://orcid.org/0000-0001-5427-7716
- Amirmansour Alavi Naeini1
- Ali Esmaeli Nadimi2 2- Dept. of Social Medicine, School of Medicine, Rafsenjan University of Medical Sciences, Rafsanjan, Iran.
- Mahmood Sheikh Fathollahi3 3- Dept. of Internal Medicine, School of Medicine, Rafsenjan University of Medical Sciences , Rafsanjan, Iran.
DOI:
https://doi.org/10.22100/jkh.v13i3.1211Keywords:
Green tea, Coronary Artery Disease, Antioxidant, Lipid profile, Blood pressureAbstract
Introduction: Coronary Artery disease is one of the major reasons of death and disability. The Aim of this study is to determine the Effectiveness of green tea on biochemical and inflammatory and antioxidant parameters in patients with coronary artery disease.
Methods: This clinical trial study was done in Rafsanjan city, the south east of Iran, from October 2016 to March 2017. Seventy two patients with coronary artery disease were enrolled in two case and control groups. The case group was received 4 green tea bags daily during 8 weeks. Anthropometric, biochemical and antioxidant evaluation and blood pressure measurement in two groups before and after the intervention were done. Antioxidants intake and diet change during intervention were evaluated.
Results: Mean and standard deviation of age and weight of patients in case group was 60.78±11.78 years and 73.03± 11.62 kg and in control group was 62.6±10.8 years and 74.03±12.2 kg. Both groups were adjusted in terms of age, BMI, gender and there was no significant difference in educational level, history of heart disease, addiction, smoking, and dietary antioxidants intake. Green tea intake caused a significant decrease in weight, body mass index, Waist circumference, triglyceride, MDA, IL6, fasting blood sugar, systolic and diastolic blood pressure (P<0.05). The mean of HDL and TAC were significantly increased after intervention (P<0.05).
Conclusion: Green tea consumption in patient with CAD disease for 8 weeks had beneficial effects on weight loss, BMI and waist circumference. It improved lipid profile, antioxidant parameters and decrease systolic and diastolic blood pressure in patients.
References
Mendonça MI, Reis RPD, Brehm A. Prediction of Coronary Heart Disease Risk in a South European Population: A Case-Control Study. Coronary Artery Diseases: InTech 2012. doi:10.5772/29995
Sayols-Baixeras S, Lluís-Ganella C, Lucas G, Elosua R. Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants .Appl Clin Genet 2014;7:15-32. doi:10.2147/TACG.S35301
McCullough PA. Coronary artery disease. Clinical Journal of the American Society of Nephrology 2007;2:611-6.
Mendis S, Puska P, Norrving B. Global atlas on cardiovascular disease prevention and control. World Health Organization 2011:p. 164.
Islam MA. Cardiovascular effects of green tea catechins: progress and promise. Recent patents on cardiovascular drug discovery 2012;7:88-99.
Wolfram S. Effects of Green Tea and EGCG on Cardiovascular and Metabolic Health. J Am Coll Nutr 2007;26:373S-88S.
Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med 2016;4:256. doi:10.21037/atm.2016.06.33
Masoumi MA, Saeidi MR, Piri F, Abdoli GR. Epidemiological Evaluation of Coronary Artery Disease (CAD) in Patients Referred to Cardiovascular Centers of Kermanshah (2001-2002). Journal of Kermanshah University of Medical Sciences (J Kermanshah Univ Med Sci) 2004;8:e81336.
Finegold JA, Asaria P, Francis DP. Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. Int J Cardiol 2013;168:934-45. doi:10.1016/j.ijcard.2012.10.046
Buja LM. Coronary Artery Disease. In: Willerson JT, Holmes DR, editors.: Springer London; 2015. p. 1.
Khan N, Mukhtar H. Tea and Health: Studies in Humans. Curr Pharm Des 2013;19:6141-7.
da Silva Pinto M. Tea: A new perspective on health benefits. Food Research International 2013;53:558-67. doi:10.1016/j.foodres.2013.01.038
Sherwani SK, Bashir A, Haider SS, Shah MA. Thrombolytic potential of aqueous and methanolic crude extracts of. Journal of Pharmacognosy and Phytochemistry 2013;2(1):125-29
Mbata T, Debiao L, Saikia A. Antibacterial activity of the crude extract of Chinese green tea (Camellia sinensis) on Listeria monocytogenes. African journal of Biotechnology 2008;7.
Sabhapondit S, Karak T, Bhuyan LP, Goswami BC, Hazarika M. Diversity of catechin in northeast Indian tea cultivars. Scientific World Journal 2012;2012:485193. doi:10.1100/2012/485193
Hamilton-Miller JM. Antimicrobial properties of tea (Camellia sinensis L). Antimicrob Agents Chemother 1995;39:2375-7.
Hassanain E, Silverberg JI, Norowitz KB, Chice S, Bluth MH, Brody N, et al. Green tea (Camelia sinensis) suppresses B cell production of IgE without inducing apoptosis. Ann Clin Lab Sci 2010;40:135-43.
Choi YB, Kim YI, Lee KS, Kim BS, Kim DJ. Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats. Brain Res 2004;1019:47-54. doi:10.1016/j.brainres.2004.05.079
Koutelidakis AE, Rallidis L, Koniari K, Panagiotakos D, Komaitis M, Zampelas A, et al. Effect of green tea on postprandial antioxidant capacity, serum lipids, C-reactive protein and glucose levels in patients with coronary artery disease. Eur J Nutr 2014;53:479-86. doi:10.1007/s00394-013-0548-0
Suliburska J, Bogdanski P, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients. Biol Trace Elem Res 2012;149:315-22. doi:10.1007/s12011-012-9448-z
Kuriyama S, Shimazu T, Ohmori K, Kikuchi N, Nakaya N, Nishino Y, et al. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA 2006;296:1255-65. doi:10.1001/jama.296.10.1255
Sano J, Inami S, Seimiya K, Ohba T, Sakai S, Takano T, et al. Effects of green tea intake on the development of coronary artery disease. Circ J 2004;68:665-70.
Miller PE, Zhao D, Frazier-Wood AC, Michos ED, Averill M, Sandfort V, et al. Associations of Coffee, Tea, and Caffeine Intake with Coronary Artery Calcification and Cardiovascular Events. Am J Med 2017;130:188-97. e5. doi:10.1016/j.amjmed.2016.08.038
Rietveld A, Wiseman S. Antioxidant effects of tea: evidence from human clinical trials. J Nutr 2003;133:3285S-92S. doi:10.1093/jn/133.10.3285S
Il'yasova D, Martin C, Sandler RS. Tea intake and risk of colon cancer in African-Americans and Whites: North Carolina colon cancer study. Cancer Causes Control 2003;14:767-72.
Zuo Y, Chen H, Deng Y. Simultaneous determination of catechins, caffeine and gallic acids in green, Oolong, black and pu-erh teas using HPLC with a photodiode array detector. Talanta 2002;57:307-16.
Wu CD, Wei GX. Tea as a functional food for oral health. Nutrition 2002;18:443-4.
McKay DL, Blumberg JB. The role of tea in human health: an update. J Am Coll Nutr 2002;21:1-13.
Saito E, Inoue M, Sawada N, Shimazu T, Yamaji T, Iwasaki M, et al. Association of green tea consumption with mortality due to all causes and major causes of death in a Japanese population: the Japan Public Health Center-based Prospective Study (JPHC Study). Ann Epidemiol 2015;25:512-8. e3. doi:10.1016/j.annepidem.2015.03.007
Tachjian A, Maria V, Jahangir A. Use of herbal products and potential interactions in patients with cardiovascular diseases. J Am Coll Cardiol 2010;55:515-25. doi:10.1016/j.jacc.2009.07.074
Bogdanski P, Suliburska J, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutr Res 2012;32:421-7. doi:10.1016/j.nutres.2012.05.007
Brown AL, Lane J, Holyoak C, Nicol B, Mayes AE, Dadd T. Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial. Br J Nutr 2011;106:1880-9. doi:10.1017/S0007114511002376
Suzuki-Sugihara N, Kishimoto Y, Saita E, Taguchi C, Kobayashi M, Ichitani M, et al. Green tea catechins prevent low-density lipoprotein oxidation via their accumulation in low-density lipoprotein particles in humans. Nutr Res 2016;36:16-23. doi:10.1016/j.nutres.2015.10.012
Wu AH, Spicer D, Stanczyk FZ, Tseng CC, Yang CS, Pike MC. Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women. Cancer Prev Res (Phila) 2012;5:393-402. doi:10.1158/1940-6207.CAPR-11-0407
Clark AM. Natural products as a resource for new drugs. Pharmaceutical research 1996;13:1133-41.
Moradi H, Kolahdozi S, Ahmadi Kani Golzar F, Arabzade H, Asjodi F, Rezvan K. The effects of eight weeks resistance training and green tea supplementation on cardiovascular risk factors in overweight men. J Shahrekord Univ Med Sci 2014;16:77-87. [Persian].
Hsu CH, Tsai TH, Kao YH, Hwang KC, Tseng TY, Chou P. Effect of green tea extract on obese women: A randomized, double-blind, placebo-controlled clinical trial. Clin Nutr 2008;27:363-70. doi:10.1016/j.clnu.2008.03.007
Chen IJ, Liu CY, Chiu JP, Hsu CH. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial. Clin Nutr 2016;35:592-9. doi:10.1016/j.clnu.2015.05.003
Nogueira LP, Nogueira Neto JF, Klein MR, Sanjuliani AF. Short-term Effects of Green Tea on Blood Pressure, Endothelial Function, and Metabolic Profile in Obese Prehypertensive Women: A Crossover Randomized Clinical Trial. J Am Coll Nutr 2017;36:108-15. doi:10.1080/07315724.2016.1194236
Ohmori R, Kondo K, Momiyama Y. Antioxidant Beverages: Green Tea Intake and Coronary Artery Disease. Clin Med Insights Cardiol 2014;8(Suppl 3):7-11. doi:10.4137/CMC.S17072
Peng X, Zhou R, Wang B, Yu X, Yang X, Liu K, et al. Effect of green tea consumption on blood pressure: A meta-analysis of 13 randomized controlled trials. Sci Rep 2014;4:6251. doi:10.1038/srep06251
Onakpoya I, Spencer E, Heneghan C, Thompson M. The effect of green tea on blood pressure and lipid profile: a systematic review and
meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis 2014;24:823-36. doi:10.1016/j.numecd.2014.01.016
Ohmori R, Kondo K, Momiyama Y. Antioxidant beverages: green tea intake and coronary artery disease. Clin Med Insights Cardiol 2014;8(Suppl 3):7-11. doi:10.4137/CMC.S17072
Venables MC, Hulston CJ, Cox HR, Jeukendrup AE. Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am J Clin Nutr 2008;87:778-84. doi:10.1093/ajcn/87.3.778
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
