Role of rs10840293 and rs17087335 in patients with coronary artery disease in an Iranian population

Authors

  • Mahdi Hesam1 1- Dept. of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
  • Mehdi Sadeghi2 2- Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Fateme Sadat Bitaraf3 3- Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran. orcid http://orcid.org/0000-0002-5851-582X
  • Rahimeh Eskandarian4 4- Dept. of Internal Medicine, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
  • Asghar Shayannia5 5- Dept. of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. orcid http://orcid.org/0000-0002-8837-4861

DOI:

https://doi.org/10.22100/jkh.v15i2.2441

Abstract

Introduction: Previous genome-wide association studies (GWASs) have shown an increased CAD risk associated with single nucleotide polymorphisms (SNPs) in SWAP70 (rs10840293) and Rest- NOA1 (rs17087335). This study aimed to investigate the relationship between rs10840293 and rs17087335 polymorphism with coronary artery disease in the Iranian population.

Methods: This study was a case-control study with the case-base sampling method for the control group. Genomic DNA was extracted from the peripheral blood collected from 150 patients with CAD and 150 healthy controls. Polymorphisms were genotyped by Taq-Man technology. SPSS software was used for statistical analysis.

Results: The genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (P>0.05). Allelic frequencies and genotype distributions of rs10840293 and rs17087335 did not show statistical significance between patients with POAG and control subjects (P<0.05).

Conclusion: To the best of our knowledge, this is the first report concerning the association between SWAP70 and Rest- NOA1 gene polymorphisms and CAD in an Iranian population. Our data suggest that rs1533428 and rs12994401 are unlikely major risk factors for CAD in an Iranian population.

Additional Files

Published

2020-10-04

Issue

Vol 15, No 2:2020

Section

Original Article(s)

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Role of rs10840293 and rs17087335 in patients with coronary artery disease in an Iranian population. (2020). Knowledge and Health in Basic Medical Sciences, 15(2), Page:51-57. https://doi.org/10.22100/jkh.v15i2.2441

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