Journal of Knowledge & Health1735-577X11220160315The Effect of 8 Weeks of HIT Workouts Plasma Levels of TNF-a, IL-6 and Lipid Profile in Overweight Children243110.1234/knh.v11i2.1181FAAbdolrezarezaKazemiDept. of Physical Education, School of Literature and Humanities, University of Vali-E-Asr, Rafsanjan, Iran.. a.kazemi@vru.ac.irKhaterehShahrokhi201508192016020720160115Introduction: The prevalence of obesity among children and adolescents around the world alarmingly are increasing. Regular exercise can reduce fat tissue and improve body composition. The aim of this study was the effect of the high intensity interval training (HIT) on plasma levels of TNF-a, IL-6 and lipid profile in overweight children. Methods: The present study was semi experimental research that performed in Tehran at 2014 year.  In this study, 32 overweight students 8 to 11 divided in the experimental (n=16) and control (n=16) group. High intensity interval training including 30 seconds with maximum speed and 5.1 minutes rest was performed for 8 weeks and 3 sessions per week. The six HIT workouts in the first week increased to 10 to last week. Blood samples were collected from venous blood of right hand 48 hours last session. ANCOVA test performed for compared of variable mean (α=0.005). Results: The results of the present study showed that 8 weeks HIT significantly reduced level of IL-6 (P=0.001), TNF-a (P=0.001) and lipid profile. On the other hand, there was insignificantly change in TG (P=0.777), LDL (P=0.071) and HDL (P=0.693). Conclusion: The findings of this study showed that 8 weeks HIT reduces the plasma level of TNF-a and IL-6. Therefore, perform of high intensity interval training with observed necessaryw55 caution in obese children can have positive effects.