Journal of Knowledge & Health1735-577X11420170205Investigating the Percentage of Th1 lymphocytes in Peripheral Blood of Patients with Autosomal Recessive Hyper-IgE Syndrome566210.1234/jkh.v11i4.1577FAArezouRahimiDepartment of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran,Iran. arezoorahimi378@gmail.comZahraChavoshzadNimaRezaeiMahboubehMansouriDelaraBabaieMohammadNabaviHamidFarajifardAmirAtashiMehrdadAmirmoiniRazeyeRezaeiRezaAlimohammadiMehrnazMesdaghi201609272016121320161116Introduction: Hyper-IgE syndrome is a primary immunodeficiency disease, characterized by increased susceptibility to a limited range of fungal and bacterial infections, especially Candida Albicans and Staphylococcus Aureus. The study of different subtypes of lymphocytes would be helpful in understanding of the disease pathogenesis. In this study, the percentage of Th1 lymphocytes in peripheral blood of patients with autosomal recessive hyper-IgE syndrome was investigated.Methods: In this case-control study, six patients with autosomal recessive hyper IgE syndrome and seven healthy controls, which were age and sex matched, were studied. Peripheral blood mononuclear cells were isolated from venous blood. After cell stimulation and culture for 12 hours, the percentage of Th1 cells was evaluated by flow cytometry.Results: The results of this study showed that the percentage of Th1 cells was significantly decreased in patients compared to the control group (P<0.005).Conclusion: The reduction in Th1 lymphocytes may play an important role in the pathogenesis of autosomal recessive hyper-IgE syndrome and their increased susceptibility to bacterial and fungal infections.