Journal of Knowledge & Health in Basic Medical Sciences1735-577X13120180526Effects of Combined Exercises beside Consumption of Omega-3, L-Carnitine Supplements on the Serum Level of Irisin, Resistance Insulin, Profile Lipid of Type 2 Diabetic Women556410.22100/jkh.v13i1.1747FAAliORCID: 0000-0002-1559-0926Hassani1*1- Dept. of Sports Physiology, School of Physical Education, Shahrood University of Technology, Shahrood, Iran.. hassani_3@yahoo.comMasoumeGhorbani2201709032018043020180224Introduction: Determining the effect of combined exercises along with the consumption of omega-3 and L-carnitine on the serum level of Irisin, resistance insulin, and profile lipid of type 2 diabetic women.Methods: In this clinical trial study, 58 female volunteer with type 2 diabetes, were randomly divided into 6 groups of 10 persons: 1. exercise + placebo; 2. exercise + omega-3 supplement; 3. exercise + L-carnitine supplement; 4. exercise + L-carnitine + omega-3 supplements; 5. omega-3 + L-carnitine supplements; and 6. control group. Combined Exercises (8 week, 3 sessions per week) included a 30 minutes aerobic exercise of running on a treadmill, and 30-40 minutes resistance exercise of circular. The omega-3 group consumed 2 capsules (each 1,000 mg) of omega-3 each day, and the L-carnitine group consumed 500 mg L-carnitine each day. The consent forms and the health questionnaires and physical activity (PAR-Q) were completed by the participants. Results were analyzed by SPSS.Results: The findings were evaluated among women with a mean age of 52.7±6.1 (years). Serum level of irisin in s was significantly increased in group 2 (P=0.02) and 4 (P=0.04). A significant HDL increase was observed in groups 4 and 5 (P=0.005), and a significant TG decrease was observed in groups 2 (P=0.01), 4 (P=0.03), and 5 (P=0.05). Resistance insulin had a significant decrease in group 2 and 5 (P=0.04), (P=0.01).Conclusion: Results showed that exercise + omega-3 supplement, and exercise + L- carnitine + omega-3 supplements were more appropriate stimuli than other groups to increase Irisin level, and reduce the diabetes risk.