Journal of Knowledge & Health in Basic Medical Sciences1735-577X14320191223The Effects of Twelve Combined Training and Portulaca Oleracea Supplementation on Lipid Profile and Liver Parenchyma in Obese Females with non - Alcoholic Fatty Liver Disease: A Clinical Trial314110.22100/jkh.v14i3.2268FANargesHttps://orcid.org/0000-0002-8369-9261Aliniya11- PhD Student of Exercise Physiology, Dept. of Physical Education and Sport Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran.. narges.aliniya63@gmail.comAlirezaHttps://orcid.org/0000-0002-6266-0018Elmieh2MohamadrezaHttps://orcid.org/0000-0003-0265-5329Fadaei3201908132019120820191130Introduction: Non-alcoholic fatty liver disease is a type of accumulation of fat in the liver cells. Portulaca oleracea has hypolipidemic properties, therefore the aim of this study was to investigate the effect of twelve combined training and portulaca oleracea supplementation on lipid profile and liver parenchyma in obese females with non - alcoholic fatty liver disease.Methods: The study population consisted of obese women (40-60 years) with non-alcoholic liver fatty. 40 obese females with non -alcoholic fatty liver disease were randomly divided into four groups of combined training with portulaca oleracea (n=10), placebo (n=10), portulaca oleracea (n=10) and combined training (n=10). Before and after the intervention sonography of parenchyma of the liver and blood tests were performed .the paired samples t-test, one-way anova and wilcoxon test was used. The significant level was determine at P<0.05.Results: 12 weeks of portulaca oleracea supplementation and combined training caused significant decrease in profile lipid and significant increase HDL serum level in combined training with supplement group, supplement and combined training groups (P<0.05). liver parenchyma also improved in training with supplement group and training group.Conclusion: Portulaca oleracea supplementation with combination training can be effective in decrease profile lipid and improving liver parenchyma in obese females with nonalcoholic fatty liver.