Knowledge & Health8320130531Evaluating the Effects of Regular Exercise and Magnesium Sulfate on Pain Threshold in Diabetic Rats333310.1234/knh.v8i3.33FAAliHeidarianpour. Heidarian317@gmail.comHadiKochekkhani120130813Introduction: Peripheral neuropathy is an important complication of diabetes mellitus. It has been shown that hyperglycemia and oxidative stress are major etiological factors in neuropathy and   contribute to its development. Since regular exercise and oral magnesium supplementation can reduce hyperglycemia induced by diabetes  and also have antioxidant effects, therefore this study was designed to examine   the effects of regular exercise and magnesium sulfate administration on thermal pain threshold  in streptozocin-induced diabetic rats.Methods: 30 male Wistar rats weighed 220±10 gwere made diabetic by streptozotocin (60 mg/kg, subcutaneously). One week after diabetes induction, animals were undergone  swimming training and magnesium sulfate treatment for 8 weeks; first, they  swim 60 min for 3 weeks, then 90 min for 2 weeks, and finally 120 min for 3 weeks. Magnesium sulfate (10 g/l) was added into the drinking water once diabetes was established (One week after diabetes induction) and continued for 8 weeks. 48 h after  the end of each stage,  tail-flick test was performed to assess the effects of training and magnesium sulfate on thermal pain threshold. The comparison of means was done using independent- sample t-test and repeated measure analysis of variance.Results: A significant decrease in thermal pain threshold was seen in diabetic rats through 5 and 8 weeks.  Diabetic induced hyperalgesia were decreased significantly by training and magnesium sulfate.  Combined effects of training and magnesium sulfate on thermal pain threshold are significantly higher than one of them alone.Conclusion: It is concluded that regular exercise and magnesium sulfate administration  may be able torestore thermal hyperalgesia in diabetes.  Future studies are required to establish the effects of these factors on treatment and/or management of painful conditions.