Knowledge & Health9120131118The Effect of Silymarin Supplementation and Endurance Training on the Plasma malondialdehyde (MDA) levels, in Sedentary Men38238210.1234/knh.v0i0.382FAAliHassani. hassani_3@yahoo.comKamranSoleimanianHassanBahrololomAdelDonyaei20131118Introduction: The aim of this study was to investigate the effect of silymarin supplementation and endurance training on the levels of MDA in sedentary men. Methods: The research was semi-experimental, and 19 subjects were selected form all sedentary male students of Shahroud university, and after obtaining consent, subjects were randomly divided into intervention group (n = 11) and placebo group (n = 8). For 6 weeks, both groups received either Silymarin supplements or placebo, along with endurance training. Blood samples were collected before and after receiving training and supplement for measuring lipid peroxidation. Data was analyzed using SPSS16 software and repeated measure analysis of variance (2×2).Results: Silymarin supplementation along with endurance training caused a significant reduction in plasma MDA levels in supplement groups as compared with placebo group (P≤0.012).Conclusions: Receiving endurance training along with silymarin supplement caused significant reduction of lipid peroxidation comparing with placebo group. It seems that the type, duration and intensity of exercise along with the dose of Silymarin supplement intake could affect MDA index.