Investigation of the Effect of Cardiac Rehabilitation Program on Peripheral Blood Mononuclear Cells ABCA1 Gene Expression in Myocardial Infractions Patient
DOI:
https://doi.org/10.22100/jkh.v11i4.1523Keywords:
Moderate resistance training, ABCA1 gene, Reverse cholesterol transportAbstract
Introduction: Atherosclerotic heart disease is a major important cause of mortality in most countries. ABCA1 transporter is responsible for making and forming of HDL particles and therefore probably plays a crucial role in prevention of atherosclerosis. The purpose of this study was to assess the effect of rehabilitation training on ABCA1 gene expression of peripheral blood mononuclear cells (PBMN).
Methods: Twenty three myocardial infractions patients were randomly selected and assigned into two groups; control (N=11) and experimental (N=12). Moderate resistance training was conducted by experimental group for 60 minutes at three sessions for eight weeks with 40-60% of one repetition maximum (1RM). Blood sample of subjects were collected before and after training. PBMN cells were separated and m-RNA purification was performed by real–time PCR. Data was analyzed by ANCOVA in SPSS software (significant leve equal 0.05).
Results: Results showed that expression of PBMN ABCA1 m-RNA was significantly increased with moderate resistance training in myocardial infractions patient group. There was no significant differences in mean of HDL-C, LDL-C (P>0.05).
Conclusion: As result that moderate resistance training increases the expression of ABCA1 gene on PBMN cells of MI patient, improves the function of reverse cholesterol transfer, and probably prevents repetition of Ischemic.
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