This is a preview and has not been published. View submission

Investigating Serum Electrolyte Disorders in Hospitalized Children with Fever and Seizures

Authors

DOI:

https://doi.org/10.22100/jkh.v19i2.3178

Keywords:

Fever, Convulsions, Children, Electrolytes

Abstract

Introduction: A febrile seizure is a convulsion in a child that's caused by a fever. Disruptions in the balance of serum electrolytes significantly contribute to the onset of these issues. This study aimed to investigate serum electrolyte abnormalities in hospitalized children experiencing fever and seizures.

Methods: In this cross-sectional study, a census was conducted to examine all children hospitalized with fever and convulsions at Taleghani Hospital in Gorgan during the years 2013 and 2014. Demographic information, seizure type, recurrence, and test results of patients were gathered using a checklist developed from the data available in the patients' inpatient records and the hospital's information system. Spearman and Mann-Whitney correlation tests were performed using software for statistical analysis.

Results: The study's results indicated that the average age of the patients was 22.6 ± 13.9 months, with 117 of them (54.7%) being boys.The findings revealed an inverse and significant relationship between age and serum levels of potassium, calcium, and magnesium; however, no such relationship was found between age and sodium serum levels. Additionally, there was no correlation between gender, type of fever and seizures, or the recurrence of seizures with serum levels of sodium, potassium, calcium, and magnesium.

Conclusion: It appears that measuring serum electrolytes in children with fever and convulsions should be conducted on a case-by-case basis, guided by a physician's assessment.

References

Hawas AF, Al-Shalah HH, Al-Jothary AH. The impact of electrolytes in pathogenesis of simple febrile convulsions. Med J Babylon 2018;15:12-15. doi: 10.4103/MJBL.MJBL_4_18

Salehiomran M, Ebrahimzadeh H, Hajiahmadi M. The serum sodium levels and recurrence of simple febrile seizure during the first 24 hours in children. Caspian J Pediatr 2018;4:278-81. doi: 10.22088/CJP.BUMS.4.1.278

Khosroshahi N GL, Kamrani K. Evaluation of magnesium levels in serum and cerebrospinal fluid of patients with febrile convulsion hospitalized in Bahrami Hospital in Tehran in 2010-2011. Acta Med Iran 2015;7:81-87.

Akbayram S, CEMEK M, Büyükben A, Aymelek F, Karaman S, Yilmaz F, et al. Major and minor bio-element status in children with febrile seizure. Bratisl Med J 2012;113:421-423. doi: 10.4149/bll_2012_095

Güneş A, Fidan S, Dulkadir R, Ünlü E. Evaluation of risk factors associated with first episode febrile seizure. Eur Rev Med Pharmacol Sci 2021;25:7089-92. doi: 10.26355/eurrev_202111_27261

Lee J-H, Kim JH. Comparison of Serum Zinc Levels Measured by Inductively Coupled Plasma Mass Spectrometry in Preschool Children with Febrile and Afebrile Seizures. Ann Lab Mede 2012;32:190-3. doi: 10.3343/alm.2012.32.3.190

Çığrı E, İnan FÇ. Comparison of Serum Selenium, Homocysteine, Zinc, and Vitamin D Levels in Febrile Children with and without Febrile Seizures: A Prospective Single-Center Study. Children 2023;10:1-10. doi:10.3390/children10030528

Maksikharin A, Prommalikit O. Serum sodium levels do not predict recurrence of febrile seizures within 24 hours. J Paediatr Child Health 2015;35:44-6. doi: 10.1179/2046905514Y.0000000159

Miyagi Y, Sasano T, Kato H, Kin K. Hyponatremia and recurrent febrile seizures during febrile episodes: a meta-analysis. Cureus 2022;14:1-11. doi: 10.7759/cureus.24398

Baek S-J, Byeon JH, Eun S-H, Eun B-L, Kim G-H. Risk of low serum levels of ionized magnesium in children with febrile seizure. BMC Pediatr 2018;18:1-6. doi: 10.1186/s12887-018-1271-z

Tseng T, Seagroves A, Tanawattanacharoen VK, Liang MC, Koppin CM, Keenan M, et al. Electrolyte abnormalities and stress dosing predict illness‐related hospitalizations among infants and toddlers with congenital adrenal hyperplasia. Clin Endocrinol 2023;98:536-42. doi: 10.1111/cen.14876

Gupta H, Sharma B, Verma M, Singh VK, Verma R. Association of serum iron and serum calcium levels in children with febrile seizures. Indian J Med Sci 2024;76:17-21. doi: 10.25259/IJMS_136_2023

Saghazadeh A, Mahmoudi M, Meysamie A, Gharedaghi M, Zamponi GW, Rezaei N. Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis. Nutrition Reviews 2015;73: 760-79. doi: 10.1093/nutrit/nuv026

Mhaibes SH, Al-Anbaki MS, Saleh E. The role of electrolytes and inflammatory biomarkers in the development of febrile seizure in children. Ann Trop Med Public Health 2020;23:111-4. doi: 10.36295/ASRO.2020.231365

Sisodiya S. Feverish prospects for seizure genetics. Nat Genet 2014;46:1255-6. doi: 10.1038/ng.3150

Amouian S, Mohammadian S, Behnampour N, Tizrou M. Trace elements in febrile seizure compared to febrile children admitted to an academic hospital in Iran, 2011. J Clin Diagn Res 2013;7:2231. doi: 10.7860/JCDR/2013/5548.3478

Namakin K, Zardast M, Sharifzadeh G, Bidar T, Zargarian S. SerumTrace elements in febrile seizure: A Case-control study. Iran J Child Neurol 2016;10:57-60.

Shrestha D, Dhakal AK, Shakya H, Shakya A, Shah SC, Mehata S. Clinical characteristics of children with febrile seizure. J Nepal Health Res Counc 2014;12:162-6.

Yousefichaijan P, Dorreh F, Abbasian L, Pakniyat AG. Assessing the prevalence distribution of abnormal laboratory tests in patients with simple febrile seizure. J Pediatr Neurosci 2015;10:93-7. doi: 10.4103/1817-1745.159180

Published

2024-08-24

Issue

Section

Original Article(s)

How to Cite

Investigating Serum Electrolyte Disorders in Hospitalized Children with Fever and Seizures. (2024). Knowledge and Health in Basic Medical Sciences, 19(2), page:40-45. https://doi.org/10.22100/jkh.v19i2.3178

Most read articles by the same author(s)

<< < 10 11 12 13 14 15 16 17 18 19 > >>