Investigation the Effect of Alcoholic Extract Carum Copticum on Wound Healing among Induced Diabetic Rats
Authors
-
Sanaz Tabatabaei1
1- College of Basic Sciences, Islamic Azad University, Damghan Branch, Damghan, Iran.
http://orcid.org/0000-0001-8028-7272
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AbdolHossein Shiravi 2
2- College of Basic Sciences, Islamic Azad University, Damghan Branch, Damghan, Iran.
http://orcid.org/0000-0001-8028-7272
- Vida Hojati3 3- College of Basic Sciences, Islamic Azad University, Damghan Branch, Damghan, Iran.
DOI:
https://doi.org/10.22100/jkh.v13i2.1945Abstract
Introduction: One of the serious complications of diabetes is the delay in wound healing. Currently, in Iran, disinfectant solutions and antibiotics are used to treat wounds and prevent infection by stopping the growth of pathogenic agents. However it cannot stimulate and initiate the wound healing process. Herbal remedies have beneficial effects on the process of wound healing, and on the other hand due to fewer complications, the tendency to use them has increased. The aim of this study was to investigate the effect of alcoholic extract Carum Copticum on wound healing in induced diabetic rats.
Methods: In this study, 48 adult male rats were divided into four groups (n=12 each) including: control group (non-treated and non-diabetic rats), sham (eucerin-treated diabetic rats), the first experimental group (non-treated diabetic rats) and the second experimental group (raspberry-treated diabetic rats). Diabetes was induced by 55 mg/kg Streptozotocin (STZ) in three groups of rats. A wound with 3 cm length was created on the skin of back side of animals in all groups. The first experimental group was treated by eucerin and the second experimental group was treated by raspberry extract two times in a day. Microscopic and macroscopic studies were performed on wound healing process on 4th, 7th, 14th and 21st days.
Results: The findings showed that sham and the first experimental group had fewer healing effect comparing with control group. The speed of wound healing in raspberry extract-treated rats (the second Experimental group) had significantly increased in comparison with control group and the wound surface area has been significantly decreased in comparison with all other groups (P≤0.05).
Conclusion: It seems that topical application of raspberry extract can accelerate the wound healing in diabetic rats and also materials in raspberry extract can stimulate the collagen synthesis and make wound contraction faster.
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