The Review of Short-Term Concurrent Training on Expression of P53 and P21 Tumor Suppressor Genes in Men with Prostate Cancer

Abstract

Introduction: Prostate cancer is one of the most important causes of cancer deaths in men. The presence of tumor suppressor proteins is one of the regulatory mechanisms for controlling the progression of the disease. The purpose of this study was to investigate the review of short-term concurrent training on expression of P53 and P21 tumor suppressor genes in men with adenocarcinoma type of prostate cancer.

Methods: In this semi-experimental study, by referring to the pathology department of the Baqiyatallah El - Azam Subspeciality Hospital in Tehran and reviewing the medical records of men with prostate cancer in the first six months of 2016, twenty men with adenocarcinoma type of prostate cancer at the T1 and T2 stage with an average age 62.60±7.71 years and body mass index 26.10 ± 3.40 kg / m2 were randomly selected and divided into control (n=10) and experimental (n=10) groups. The experimental group performed Concurrent Training for three days a week within eight weeks, including resistance training with 60-75% of a maximal repeat and aerobic exercise with 60-75% of maximum heart rate. The expression of P53 and P21 genes was measured by Real-Time PCR and analyzed by independent/paired T test.

Results: The results showed that short-term concurrent training increased significantly P53 gene expression (P=0.000) and P21 gene expression (P=0.00) in the experimental group, and compared with the control group (P=0.00). There was no significant difference between P21 and P53 gene expression in the control group (P>0.05).

Conclusion: Significant increase in aerobic power and muscle strength following short-term concurrent training and its consequent significant increase in tumor suppressor proteins may possibly reduce the progression of adenocarcinoma type of prostate cancer tumors.