Reducing Cadmium Induced Bone Marrow Toxicity Using Hydro-Alcoholic Extract of F.Felabeliluba

Abstract

Introduction: Lead as a heavy metal at the same time as industrial development has become one of the most important pollutants that has irreparable health effects. The purpose of the present study was to investigate the protective effects of hydro-alcoholic extract on lead induced bone marrow toxicity.

Methods: In this experimental study, 30 male Wistar rats were randomly divided into 5 groups. Control group (physiological serum), lead group 20 mg / kg, lead group + 100 mg / kg Ferulla, 300 mg / kg, 600 mg / kg Ferulla. The groups were exposed with Pb via IP injection for one week. Then the treatment was performed with Ferulla extract in different doses for one week. Then mice were anesthetized and a cardiac blood sample in EDTA obtained. Femoral bone samples were also isolated from the mice. The indexes of Hb, Hct, RBC, WBC, PLT and comet indexes were evaluated.

Results: The results showed that there was a significant decrease in hematological indices in lead toxicity compared to sham. Also, the DNA fracture in the poisoning group was significantly higher than that of sham. Treated groups with Ferulla. exhibited recovery effects in comparison with the lead induced toxicity group in a dose dependent manner.

Conclusion: Due to the mechanism of lead induced toxicity, the use of compounds with antioxidant properties can help prevent of disorder and improve complications.