Evaluation of Anticancer Effects of Echinacea Purpurea Extract on Lung Metastatic Breast Cancer Cells
Authors
- Morteza Kermani Student Research Committee, Shahroud University of Medical Sciences, Shahroud, Iran.
-
Mohammad Kamalabadi Farahani
- Ophthalmic Epidemiology Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.
https://orcid.org/0000-0002-4768-2577
- Sepehr Zamani - Student Research Committee, Shahroud University of Medical Sciences, Shahroud, Iran.
-
Anneh Mohammad Gharravi
- School of Medicien, Shahroud University of Medical Sciences, Shahroud, Iran.
https://orcid.org/0000-0001-5113-5982
DOI:
https://doi.org/10.22100/jkh.v18i3.3214Keywords:
Anticancer , Breast CancerAbstract
Introduction: Echinacea Purpurea belongs to the Asteraceae family. In traditional medicine, the extract of this plant is used to prevent and treat diseases such as the common cold, lung infections, skin disorders and chronic diseases caused by immune system deficiency. Recent studies have shown that caffeic acid in Echinacea, which is one of the phenolic substances of this plant, inhibits the proliferation of breast cancer cells by exerting antioxidant effects. In the present study, we investigate the effects of this plant extract on breast cancer lung metastatic cells.
Methods: After creating a mouse model of breast cancer, lung metastatic and primary tumor cells were isolated from the lungs and primary tumor tissues of mice, respectively. The ethanolic extract of echinacea was prepared after soaking the aerial parts of the plant in 100% ethanol for 48 hours. The cytotoxic effects of the desired extract on primary and metastatic tumor cells were determined by MTT assay.
Results: The extract of echinacea has strong cytotoxic effects on breast cancer lung metastatic cells. Interestingly, compared to primary tumor cells, lung metastatic cells are significantly more sensitive to these cytotoxic effects.
Conclusion: This is the first report of the anticancer effects of the echinacea extract on lung metastatic tumor cells. Compared to many drugs and anti-cancer compounds that have a very ability to fight against metastatic cancer cells, the extract of this plant is a suitable candidate for fighting against these cells in breast cancer.
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