Relationship between Serum Adiponectin Levels and Lipid Profiles, Testosterone and Cortisol in Sedentary Men
DOI:
https://doi.org/10.22100/jkh.v9i3.390Keywords:
Adiponectin, Lipid profile, Testosterone, Cortisol.Abstract
Introduction: Adiponectin is one of adipocytokines secreted by adipose tissue that decreases with increased insulin resistance, dyslipidemia, obesity and diabetes. The purpose of this study was to investigate relationships between serum adiponectin levels and lipid profiles, testosterone, and cortisol in sedentary men.
Methods: In semi-experimental study, forty five young men, without experience of regular physical activity during past six months were selected. After 12 h fasting (at 8 A.M.), Venous blood samples were collected for adiponectin, testosterone, cortisol and lipid profiles assessment. Moreover general characteristics of subjects were assessed. Data was analyzed using SPSS 16.0 software and the relationships were calculated by Pearson’s correlation analysis.
Results: Adiponectin levels were negatively correlated to LDL cholesterol (r=-0.25, P=0.008), triglyceride (r=-0.30, P=0.003), and testosterone levels (r =-0.41, P=0.002) and positively correlated to HDL cholesterol levels (r= 0.26, P=0.005). No significant correlations were observed between adiponectin levels with total cholesterol (r= -0.21, P=0.053) and cortisol levels (r=0.16, P=0.089).
Conclusion: It seems that in sedentary men, lower adiponectin levels are associated with dyslipidemia and consequently increased risk of metabolic syndrome and cardiovascular diseases in these subjects. Moreover, serum concentrations of adiponectin are directly correlated with testosterone levels, but it appears that there is no correlation between adiponectin levels and cortisol concentrations.
References
Ahmadizad S, Haghighi AH, Hamedinia MR. Effects of resistance versus endurance training on serum adiponectin and insulin resistance index. European Journal of Endocrinology 2007,157: 625-631.
Gale SM, Castracane VD, Mantzoros CS. Energy homeostasis, obesity and eating disorders: recent advances in endocrinology. J Nutr 2004;134:295-8.
Hamedinia MR, Haghighi AH. The effect of aerobic training on serum adiponectin and insulin resistance index in overweight men. Olympic J 2006;13(4):41-50.[Persian].
Ahima RS. Metabolic actions of adipocyte hormones: focus on adiponectin. Obesity 2006;14:9-15.
Kurl S, Laukkanen JA, Rauramaa R, Lakka TA, Sivenius J, Salonen JT. Cardiorespiratory fitness and the risk for stroke in men. Arch Intern Med 2003;163(14):1682-8.
Thompson PD, Buchner D, Pina IL, Balady GJ, Williams MA, Marcus BH. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation 2003;107:3109-16.
Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL, et al. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 2001;86(8):3815-19.
Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz CA, et al. Adiponectin is not altered with exercise training despite enhanced insulin action. Am J Physiol Endocrinol Metab 2002; 283(4):861-5.
Boudou P, Sobngwi E, Mauvais-Javis F, Vexiau P, Gautier JF. Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men. Eur J Endocrinol 2003;149:421-4.
Yokoyama H, Emoto M, Araki T, Fujiwara SH, Motoyama K, Morioka T. Effect of aerobic exercise on plasma adiponectin levels and insulin resistance in type 2 diabetes. Diabetes Care 2004;27(7):1756-8.
Hara T, Fujiwara H, Nakao H, Mimura T, Yoshikawa T, Fujmoto S. Body composition is related to increase in plasma adiponectin levels rather than training in young obese men. Eur J Appl Physiol 2005;74:520-6.
Kriketos AD, Gan SK, Poynten AM, Furler SM, Chisholm DJ, Campbell LV. Exercise increases adiponectin levels and insulin sensitivity in humans. Diabetes Care 2004;27(2):629-30.
Oberbach A, Tonjes A, Kloting N, Fasshauer M, Kratzsch J, Busse MW, et al. Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol 2006;154:577-85.
Ring-Dimitriou S, Paulweber B, von Duvillard SP, Stadlmann M, LeMura LM, Lang J, et al. The effect of physical activity and physical fitness on plasma adiponectin in adults with predisposition to metabolic syndrome. Eur J Appl Physiol 2006; 98(5):472-81.
Yatagai T, Nishida Y, Nagasaka S, Nakamura T, Tokuyama K, Shindo M, et al. Relationship between exercise training-induced increase in insulin sensitivity and adiponectinemia in healthy men. Endocrinol J 2003;50(2):233-8.
Fatouros IG, Tournis S, Leontsini D, Jamurtas AZ, Sxina M, Thomakos P, et al. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab 2005;90(11):5970-7.
Klimcakova E, Polak J, Moro C, Hejnova J, Majercik M, Viguerie N, et al. Dynamic strength training improves insulin sensitivity without altering plasma levels and gene expression of adipokines in subcutaneous adipose tissue in obese men. J Clin Endocrinol Metab 2006;91(12):5107-12.
Brooks N, Layne JE, Gordon PL, Roubenoff R, Nelson ME, Castaneda-Sceppa C. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Inter J Med Sci 2006;4:19-27.
Mohebi H, Talebi Garekanib E, Hedayati M, Fathib R. Effects of exercise training on high molecular weight adiponectin in healthy male rat. Iran J Endocrinol Metab 2009;11(9):315-21.[Persian].
Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clinical Chemistry 2004;50(9):1511-25.
Dabidiroshan V, Sadeghpour B, Jahanian Z. The effect of exhaustive running with different intensities on adiponectin concentration in active females. J Sport Biosci 2009;1(3):141-50. [Persian].
Wunder DM, Yared M, Bersinger NA, Widmer D, Kretschmer R, Birkhäuser MH. Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women. Eur J Endocrinol 2006;155(1):137-42.
Rahmani-nia F, Rahnama N, Hojjati Z, Soltani B. Acute effects of aerobic and resistance exercises on serum leptin and risk factors for coronary heart disease in obese females. Sport Sci Health 2008;2(3):118-124.[Persian].
Jackson AS, Pollock ML. Generalized equations for predicting body density of men. Br J Nutr 1978;40(3):497-504.
Siri WE. Body composition from fluid spaces and density: analysis of methods. Nutrition 1993;9(5):480-91.
Coker RH, Williams RH, Kortebein PM, Sullivan DH, Evans WJ. Influence of exercise intensity on abdominal fat and adiponectin in elderly adults. Metabolic Syndrome and Related Disprders 2009;7(4):363-369.
Mohebi H, Moghadasi M, Rahmani-Nia F, Hassan-Nia F, Noroozi H. Effect of 12 weeks life-style activity modification (LAM) on adiponectin gene expression and plasma adiponectin in obese men. Iran J Endocrinol Metab 2010;12(1):25-33.[Persian].
Rokling-Andersen MH, Reseland JE, Veierød MB, Anderssen SA, Jacobs Jr DR, Urdal P, et al. Effects of long-term exercise and diet intervention on plasma adipokine concentrations. Am J Clin Nutr 2007;86:1293-301.
Mamaghani F, Zarghami N, Maleki MJ, Pourhasan Moghadam M, Hosseinpanah F. Variation of adiponectin levels in normal and obese subjects: possible correlation with lipid profiles. International Journal of Endocrinology and Metabolism (IJEM) 2009;7(3):170-178.[Persian].
Schulze MB, Rimm EB, Shai I, Rifai N, Hu FB. Relationship between adiponectin and glycemic control, blood lipids, and inflammatory markers in men with type 2 diabetes. Diabetes Care 2004;27(7):1680-7.
Bruun J, Lihn A, Verdich C, Pedersen S, Toubro, Astrup A, et al. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 2003;285:527-33.
Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol 2003;149(4):331-5.
Ryan AS, Berman DM, Nicklas BJ, Sinha M, Gingerich RL, Meneilly GS, et al. Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. Diabetes Care 2003;26(8):2383-8.
Özkurt B, Özkurt ZN, Altay M, Aktekin CN, Çağlayan O, Tabak Y. The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. Eklem Hastalık Cerrahisi 2009;20(2):78-84.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
