مقايسه ميزان ماتريکس متالوپروتئيناز-9 در سرم و پلاسماي بيماران مبتلا به سرطان پستان

نویسندگان

  • Morteza Sadeghi دانشگاه اصفهان- دانشكده علوم- گروه زيست‌شناسي- بخش ژنتيك
  • Majid Motevali Bashi دانشگاه اصفهان- دانشكده علوم- گروه زيست‌شناسي- بخش ژنتيك

DOI::

https://doi.org/10.22100/jkh.v6i2.109

کلمات کلیدی:

سرطان پستان، ماتريکس متالوپروتئيناز-9، ميزان پلاسمايي، ميزان سرمي

چکیده

مقدمه: ماتريکس متالوپروتئيناز-9 (MMP-9) به‌تازگي به‌عنوان يکي از ژن‌هاي مارکر براي بسياري از سرطان‌ها گزارش شده است. باتوجه به يافته‌هاي قبلي درمورد اين ژن، در اين مطالعه به مقايسه ارتباط ميزان پلاسمايي و سرمي اين آنزيم با خصوصيات باليني بيماران مبتلا به سرطان پستان پرداختيم.

مواد و روش‌ها: در اين مطالعه مورد- شاهدي، 114 بيمار مبتلا به سرطان پستان به همراه 87 فرد سالم مورد تحقيق قرار گرفتند. براي بررسي ميزان MMP-9 در سرم و پلاسماي بيماران از روش زيموگرافي ژلاتين و کيت بايو رد (Bio-Rad, Richmond, CA) استفاده شد.

نتایج: ميزان MMP-9 پلاسمايي در بيماران بسيار بيشتر از افراد سالم بود و تفاوت آن بيشتر از ميزان تفاوت MMP-9 سرمي اين دو گروه بود (001/0P<). ارتباط معناداري بين افزايش ميزان MMP-9 پلاسمايي و متاستاز به غدد لنفاوي (019/0=P، 4/3OR,) و تهاجم وريدي (033/0=P، 14/4OR,) بيماران مورد مطالعه وجود داشت. ارتباط خاصي بين ميزان MMP-9 سرمي و متاستاز لنفاوي يا تهاجم وريدي مشاهده نشد.

نتیجه‌گیری: نتايج مطالعه نشان مي‌دهد که براي تشخيص زودهنگام بدخيمي سرطان پستان، ميزان پلاسمايي اين آنزيم، مناسب‌تر از ميزان سرمي آن است.

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2011-12-17

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