The Role of Endothelial-Derive Factors in Acute Mountain Sickness

Authors

  • Bayan Fayazi
  • Vahid Tadibi
  • Naser Behpour
  • Mehdi Hedayati

DOI:

https://doi.org/10.22100/jkh.v12i3.1733

Keywords:

Acute mountain sickness, VEGF, Endothelin-1

Abstract

Introduction: Acute mountain sickness (AMS) that caused by rapid ascent to altitude, is a pathophysiological symptom complex. Accordingly, aim of the study was to investigate the endothelial related factors changes in individual with a weak tolerance to high altitude.

Methods: 21 healthy male (31.7±8.5 year) participated in the study and fasting blood samples were taken from antecubital vein before (sea level) and after 1 and 24-h exposure to high altitude (3550 m) by telecabin. Then, Serum VEGF and Endothelin-1 were measured by ELISA method. AMS status was measured by the Lake Louise score at 6 h after exposure to high altitude.

Results: 11 of participants suffer from AMS. Statistical analyses showed that serum VEGF and Endothelin-1 at sea level in AMS-susceptible individuals were less than that of AMS-resistant individuals (P≤0.05). VEGF and Endothelin levels were significantly increased at 1 and 24 h after exposure to altitude in two groups (P≤0.05). The levels of VEGF and Endothelin-1 at tree time points were more in AMS-resistant individuals in compared to AMS-susceptible individuals (P≤0.05).

Conclusion: The results showed that the response of these proteins after exposure to altitude in AMS susceptibility individuals was less than AMS-resistant individuals. Susceptibility to AMS may be associated with a less response of VEGF and Endothelin-1 after exposure to altitude.

Published

2017-11-13

Issue

Section

Original Article(s)

How to Cite

The Role of Endothelial-Derive Factors in Acute Mountain Sickness. (2017). Knowledge and Health in Basic Medical Sciences, 12(3), page:17-24. https://doi.org/10.22100/jkh.v12i3.1733

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