The Effect of a Course of Sustanon Self-Administration and Omega 3 Consumption on Serum Levels of Total Cholesterol, Brain Derived Neurotrophic Factor (BDNF), High Density Lipoprotein (HDL), Low Density lipoprotein (LDL), and Alanine Aminotransferase (ALT

Abstract

Introduction:The adverse effects caused by abusing anabolic androgenic drugs include cardiovascular disorders, liver dysfunction, kidney disease, testicular problems, psychiatric and behavioral disorders in both sexes as well as other problems on human body. The purpose of this study was to investigate the effect of a course of Sustanon self-administration and Omega 3 consumption on serum levels of total Cholesterol, Brain-derived neurotrophic factor (BDNF), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and Alanine Aminotransferase (ALT) among male bodybuilders in Khorramabad city, Iran.

Methods:  In this semi-experimental study, 14 male bodybuilders (age: 28.27 ± 5.42 years; weight: 82.27 ± 10.19 kg; height: 180.07 ± 4.73 cm) voluntarily participated and randomly divided into two groups: 1) Experimental 1 (n=7, Sustanon) and 2) Experimental 2 (n=7, Sustanon and Omega 3). All subjects used Sustanon for 35 days. During this period, group 2 received an omega-3 tablet (3 grams) per day. During the course of consumption, all subjects had regular bodybuilding training. Blood samples were taken in the fasting state 48 hours before and after the course to measure serum levels of total cholesterol, HDL, LDL, BDNF, and ALT. The paired-Samples T test and ANCOVA were used to identify any significant differences and statistical significance was set at 0.05.

Results: Results of t-test showed that serum levels of BDNF and ALT increased significantly in group 1 (P<0.05), But in group 2, serum levels of BDNF and HDL increased (P<0.05) and LDL decreased significantly (P=0.03). Also, the results of covariance test showed that the difference between the two groups was significant only in serum BDNF concentrations (P=0.015), but in other variables was not significant (P>0.05).

Conclusion:The use of Sustanon alone and Sustanon with omega-3 for 35 days in male bodybuilders increased serum levels of BDNF, but co-administration of sustanon and Omega-3 was more effective.