Reduce the cadmium-induced hepatotoxicity using hydro-alcoholic extract of Ziziphoratenuior

Abstract

Introduction: Cadmium is a very toxic heavy metal that can be toxic by inducing oxidative stress in the liver. The aim of this study was to reduce the effects of liver toxicity due to exposure to cadmium using hydrocarbon extract of Zatariatenuior plants.

Methods: This study was an experiment-inteventional study in which 30 rats were injected intraperitoneally with 300 μM cadmium in 5 ml rats in 5 groups (5 mice) at a dose of 2 ml/kg body weight for 5 days. After the fifth injection, the treatment of the rats was performed using a Zataria extract at doses of 100, 300 and 600 mg/kg body weight for one month. Then, the liver was extracted and the amount of protein, glutathione, malondialdehyde, SOD and the genome failure was examined. The results were analyzed using ANOVA and the significance level was less than 0.05.

Results: Liver toxicity was associated with increased activity of liver enzymes, increased oxidative stress due to reduction of glutathione levels (P<0.05) and supercapacity dismutase (P<0.001) and increased levels of malondialdehyde (P<0.001) glutathione reductase (P<0.003) and glutathione peroxidase (P<0.005) in cadmium group compared to controls. In groups treated with hydroalcoholic extract of Zataria, reduction of liver toxicity decreased with decreased activity of liver enzymes, decreased oxidative stress due to increased levels of glutathione (P<0.05), superoxide dismutase (P<0.001) and decreased levels of malondialdehyde (P<0.001) compared to the cadmium group.

Conclusion: Hydroalcoholic extract of zataria increased the antioxidant capacity by strengthening the antioxidant defense system, reducing the toxic effects of cadmium accumulation in rat liver.