The level of seleno protein S and oxidative stress in blood plasma of type 2 diabetic patients and their correlation with blood glucose level and lipid parameters

Abstract

Introduction: Selenoprotein (SelS) S is a member of the selenoprotein family whose studies have shown that it may be involved in glucose homeostasis and lipid metabolism and antioxidant effects. The aim of study was to determine the level of seleno protein S and oxidative stress in the serum of type 2 diabetic patients and to determine their correlation with blood glucose level and lipid parameters.

Methods: This case-control study was performed on patients referred to the diabetes clinic of Imam Reza Hospital in Mashhad. 10 ml of venous blood were taken from the study subjects and serum level of SelS was measured by ELISA kit. Serum levels of HbA1c, FBS, and lipid profile were evaluated by autoanalysis.

Results: The results showed that the serum level of SelS in patients with type 2 diabetes was significantly lower than the control group (P=0.016). Also, serum levels of TAC and MDA decreased (P=0.000) and (P=0.000) in the patient group compared to the control group, respectively. It was also observed that there was a significant inverse correlation between serum SelS concentration and HbA1c level (r=0.279 and P=0.049, respectively).

Conclusion: Increased serum level of SelS in healthy subjects compared to diabetic patients and the presence of a significant relationship between diabetes biomarkers such as glycosylated hemoglobin may indicate the role and importance of SelS as a new strategy in prevention and improvement of macrovascular complications of diabetes.