The Effect of Eight Weeks of Continuous Aerobic Exercise on Some Markers of Angiogenesis in Elderly Male Rats
Authors
- Golbano Blori1 1- Ph.D. Student of Sport Physiology, Islamic Azad University, Tehran, Iran.
-
Hossein Abednatanzi2*
2- Assistant Professor, Dept. of Sport Sciences, Islamic Azad University, Tehran, Iran.
http://orcid.org/0000-0001-6638-1131
- Hojjat Allah Nikbakht3 3- Associate Professor, Dept. of Sport Sciences, Islamic Azad University, Tehran, Iran.
DOI:
https://doi.org/10.22100/jkh.v14i4.2319Keywords:
Continuous aerobic exercise, Angiosis, ElderlyAbstract
Introduction: Aging is a process in which the body's physiological capacity decreases continuously after the age of 30. One of the major changes is body mass loss (sarcopenia), which is due to decreased blood supply due to inability to exercise. The aim of this study was to investigate the effect of eight weeks of continuous aerobic exercise on some angiogenesis indices in elderly male rats.
Methods: The sample of this study consisted of 20 elderly male rats that were randomly divided into control (n=10) and experimental (n=10) groups. Eighth arrives. Blood samples were obtained from the tail of adult male rats 72 hours before and after the last session of the protocol of 3 cc (VEGF), FGF, NO and Apelin 13). Independent and dependent T-test was used for analysis of data. Inter-group and intra-group evaluation was performed. Statistical analysis was performed using SPSS 16 at α=0.05.
Results: Eight weeks of aerobic training significantly increased the levels of VEGF (P=0.000), NO (P=0.000), FGF (P=0.000) and Apelin 13 (P=0.000) mice. The male became older. No significant changes were observed in the control group.
Conclusion: The results of this study showed that eight weeks of aerobic training significantly increased the angiogenesis levels in elderly male rats. Therefore, continuous aerobic exercise can be used as an appropriate method to increase angiogenesis in the elderly.
References
Hamidizadeh S, Ahmadi F, Aslani Y, Etemadifar Sh, Salehi Kamal, Kordeyazdiet R. Study effect of a group-based exercise program on the quality of life in older men and women in 2006-2007. Journal of Shahid Sadoughi University of Medical Sciences and Health Services 2007;16:50-9.
Hortobágyi T, Mizelle C, Beam S, DeVita P. Old adults perform activities of daily living near their maximal capabilities. J Gerontol A Biol Sci Med Sci 2003;58:M453-60. doi:10.1093/gerona/58.5.m453
DiPietro L. Physical activity in aging: changes in patterns and their relationship to health and function. J Gerontol A Biol Sci Med Sci 2001;56:13-22. doi: 10.1093/gerona/56.suppl_2.13
Vogel T, Brechat PH, Leprêtre PM, Kaltenbach G, Berthel M, Lonsdorfer J. Health benefits of physical activity in older patients: a review. Int J Clin Pract 2009;63:303-20. doi: 10.1111/j.1742-1241.2008.01957.x
Noroozian M. The elderly population in iran: an ever growing concern in the health system. Iran J Psychiatry Behav Sci 2012;6:1-6.
Jones LW, Antonelli J, Masko EM, Broadwater G, Lascola CD, Fels D, et al. Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer. J Appl Physiol 2012;113: 263-72. doi: 10.1152/japplphysiol.01575.2011
Nourshahi MH, Taheri, and K. Ranjbar, The stimulus of angiogenesis during exercise and physical. QHMS, 2013. 18: p. 286-96.
Gavin TP, Wagner PD. Effect of short-term exercise training on angiogenic growth factor gene responses in rats. Journal of Applied Physiology 2001;90:1219-26. doi:10.1152/jappl.2001.90.4.1219
Lloyd PG, Prior BM, Yang HT, Terjung RL. Angiogenic growth factor expression in rat skeletal muscle in response to exercise training. Am J Physiol Heart Circ Physiol 2003;284:H1668-78. doi:10.1152/ajpheart.00743.2002
TaheriChadorneshin H, Ranjbar K, Nourshahi M. A review of response of angiogenic and angiostatic factors to exercise. The Horizon of Medical Sciences 2017;23;331-8.[Persian].
Gavin TP, Stallings HW, Zwetsloot KA, Westerkamp LM, Ryan NA, Moore RA, et al. Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans. J Appl Physiol 2005;98;315-21. doi: 10.1152/japplphysiol.00353.2004
Brown MD. Exercise and coronary vascular remodelling in the healthy heart. Exp Physiol 2003;88:645-58. doi:10.1152/ajpheart.00743.2002
Husain K. Physical conditioning modulates rat cardiac vascular endothelial growth factor gene expression in nitric oxide-deficient hypertension. Biochem biophys res commun 2004;320:1169-74. doi:10.1113/eph8802618
Hoier B, Nordsborg N, Andersen S, Jensen L, Nybo L, Bangsbo J, et al. Pro‐and anti‐angiogenic factors in human skeletal muscle in response to acute exercise and training. J Physiol 2012;590:595-606. doi:10.1113/jphysiol.2011.216135
Ranjbar K, Nourshahi M, Hedayati M, Taheri ChadorneshinH. Effect of gender and physical activity on serum vascular endothelial growth factor at rest and response to submaximal exercise. Iranian Journal of Endocrinology and Metabolism 2011;13:294-300.
Prior BM, Yang HT, Terjung RL. What makes vessels grow with exercise training? J Appl Physiol 2004;97:1119-28. doi:10.1152/japplphysiol.00035.2004
Modgil A, Guo L, O'Rourke ST, Sun C. Apelin-13 inhibits large-conductance Ca2+- mechanism. PLoS One 2013;8:e83051-63. doi: 10.1371/journal.pone.0083051
Behjati A, Babai Mazrae No A, Faramarzi M. The effect of resistance training on vascular endothelial growth factor (VEGF) in older women. Iranian Journal of Ageing 2015;10:156-65.[Persian].
Nourshahi M, Babaei A, Bigdeli Mr, Ghasemi Beyrami M. The effect of six weeks of resistance training on tumor tissue VEGF and endostatin in mice with breast cancer. Sport Biosciences (Harakat) 2013;5:27-46.[Persian].
Fathollahi Shoorabeh FL, Faramarzi M, Hemmati R, Nuri R. The effects of ten weeks resistance training on resting levels of some angiogenesis factors among men with prostate cancer. Yafte 2017;19:129-39.[Persian].
Fathollahi Shourabeh F, Tarverdizadeh B, Keihani M. The impact of eight weeks of resistance training on some angiogenesis indicators in women with breast cancer. The Iranian Journal of Obstetrics, Gynecology and Infertility 2017;20:9-17. doi:10.22038/ijogi.2017.8868
Marques E, Carvalho J, Soares JM, Marques F, Mota J. Effects of resistance and multicomponent exercise on lipid profiles of older women. Maturitas 2009;63:84-8.
Brixius K, Schoenberger S, Ladage D, Knigge H, Falkowski G, Hellmich M, et al. Long-term endurance exercise decreases antiangiogenic endostatin signalling in overweight men aged 50-60 years. Br J Sports Med 2008;42:126-9. doi:10.1136/bjsm.2007.035188
Tanaka H, Monahan KD, Seals DR. Age-predicted maximal heart rate revisited. J Am Coll Cardiol 2001;37:153-6. doi:10.1093/gerona/62.6.616
Manini T, Marko M, VanArnam T, Cook S, Fernhall B, Burke J, et al. Efficacy of resistance and task-specific exercise in older adults who modify tasks of everyday life. J Gerontol A Biol Sci Med Sci 2007;62:616-23. doi:10.1016/s0735-1097(00)01054-8
Cao ZB, Maeda A, Shima N, Kurata H, Nishizono H. The effect of a 12-week combined exercise intervention program on physical performance and gait kinematics in community-dwelling elderly women. J Physiol Anthropol 2007;26:325-32. doi: 10.2114/jpa2.26.325
Tolouei AJ, Ravasi A, Soori R, Akbarnejad A, Hemati Nafar M. The effect of 8 weeks aerobic training on angiogenesis (vegf) and angiostatic (es) factors in sedentary women. Stud Med Sci 2017;27: 1032-40.[Persian]. doi: 10.18869/acadpub.umj.27.12.1032
Amani Shalamzari S, Agha-Alinejad H, Alizadeh Sh, Kazmi AR, Saei MA, Minayi N, et al. The effect of endurance training on the level of tissue IL-6 and VEGF in mice with breast cancer. J Shahrekord Univ Med Sci 2014;16:10-21.[Persian].
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
