Assessment of Comparative Effect of Ivy Extract with Geranium on Shear Wound Healing in Rats

Abstract

Introduction: Wound is one of the clinical problems and can be acute or chronic. Due to the importance of wound management and treatment, it is one of the medical priorities. Any product and process that can minimize wound healing time can solve problems. Help patients. Wound healing is a complex and biologically dynamic process that involves the interaction of cellular and biochemical processes. This study was designed and performed to investigate the comparative effect of ivy and geranium extract on shear wound healing in rats.

Methods: In this experimental study, male Wistar rats weighing 200-250 g were used. Mice were divided into four groups of ten, which included groups without treatment (negative control), treatment with osrine (positive control), treatment with geranium extract ointment and treatment with ivy extract. In this experiment, mice were anesthetized with 5% ketamine and 2% xylazine before wounding. In the area of the skin behind the body and the midline near the injured spine, a circular incision was made in the shape of a circle with a radius of 1.5 cm and an approximate area of 7 cm2. Treatment was performed in rats once daily for 14 days. The ointment was made using osrine (ointment base) and ivy and geranium extract. Wound area was measured on days 2, 5, 8, 11, 14 after incision.

Results: The studies showed a healing process in the treatment groups of ivy and geranium extract and showed a significant increase in the percentage of wound healing compared to the negative and positive control groups (P<0.05). The healing process in both extracts was slightly different from each other. The results also showed that there was no significant difference in the percentage of wound healing between the negative control group (without treatment) and positive (Osrine recipient) and osrine had no effect on wound healing (P<0.05).

Conclusion: This study showed that ivy and geranium extract ointment accelerates the healing process of incisional wounds in rats.