The Comparison of Serum Iron, Ferritin and TIBC in Children Aged 9 Months to 6 Years having Febrile with Febrile Seizure
DOI:
https://doi.org/10.22100/jkh.v9i1.358Keywords:
Febrile seizure, Serum iron, Ferritin, Fever.Abstract
Introduction: Very small percentage of fevers has caused seizure. Changes in amounts of substances in the blood can increase or decrease the incidence of seizure. The purpose of this study was to compare serum iron and ferritin levels between children having a febrile seizures and children with fever but no seizures.
Methods: The study was conducted on 485 children who presented with febrile from 9 to 59 months referring to Imam Hossein Hospital in shahroud in the year 2011. In this study, patients were divided into two groups: The control group who had fever(n=320) without seizure, and the case group who had febrile seizure (n=165). After taking the primary actions, stabilization of vital signs and controlling the fever and convulsions, venous blood was taken from all patients, and Hb, HCT, serum iron level, ferritin and TIBC were measured with standard methods.
Results: 49.1% of the patients in the case group and 51.6% of those in the control group were male and mean age of children was 32.1 ± 14.4 months in the case group, and 34.2 ± 15.4 months in the control group. Mean duration of fever in children was 3.2 ± 1.2 days in the case group and 4.0 ± 1.2 days in the control group. The mean duration of convulsion was 1.2 ± 0.7 minute and mean seizure frequency was 1.0 ± 1.3 times. The results showed that amount of iron (P<0.003), ferritin (P<0.008) and TIBC (P<0.001) were significantly higher in cases group rather than control group. The study also showed that various levels of anemia in the control group (38.7%) was higher than control group (29.1%).
Conclusion: The finding of this research showed that the serum iron level in children with fever and convulsions were higher than children without seizure,and it seems the lower levels of iron may have a protective effect in preventing febrile seizure.
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