تأثير ده هفته ورزش هوازی بر عملکرد سیستولیک بطن چپ، سطح کاسپاز-3 و اندازه ناحیه انفارکتوس موشهای صحرایی با انفارکتوس قلبی
DOI::
https://doi.org/10.22100/jkh.v10i3.680کلمات کلیدی:
ورزش هوازی، درصد کسر تخلیه، درصد کوتاهشدگی میوفیبریلهای میوکارد، انفارکتوس قلبیچکیده
مقدمه: هدف این مطالعه، بررسي تأثير ده هفته تمرین هوازی زیر بیشینه دویدن بر عملکرد سیستولیک بطن چپ، کاسپاز-3 و اندازه ناحیه انفارکتوس در موشهای صحرايي با انفارکتوس قلبی میباشد.
مواد و روشها: 20 سر موش صحرایی نر ویستار چهار هفته بعد از انفارکتوس قلبی به دو گروه کنترل انفارکتوس شده (SedMI، 10n=) و گروه تمرینی انفارکتوس شده (ExMI، 10n=) تقسیمبندی شدند. 10 سر موش صحرايي نر ويستار بدون انفاركتوس قلبي نيز بهعنوان گروه کنترل سالم (Sham، 10n=) در نظر گرفته شدند. گروه ExMI به مدت 10 هفته تمرین ورزشی دویدن بر روی تردمیل (هر هفته 5 جلسه و هر جلسه 50 دقیقه با سرعت 17 متر بر دقیقه معادل 55 درصد ظرفیت هوازی) را انجام دادند. از تمامي موشها قبل و بعد از مداخله ورزش، اکوکاردیوگرافی بهعمل آمد.
نتايج : تجزيه و تحليل آماری دادهها نشان داد که میزان کسر تخلیه (EF) و کوتاهشدگی میوفیبریلهای عضلانی (FS) در گروههای انفارکتوس شده (Ex MI ,Sed MI) نسبتبه گروه شم ظرف 4 و 14 هفته بعد از انفارکتوس بهطور معنيداری کاهش داشت (05/0P<). میزان EF و FS در پایان هفته چهاردهم در گروه ExMI، بیشتر از گروه SedMI بود. همچنین اندازه ناحیه انفارکتوس و نرخ مرگ و میر جوندگان در پاسخ به فعالیت ورزشی بهطور معنيداری کاهش پیدا کرد (05/0P<)، اما تغییر معنيداری در اندازه فعالیت کاسپاز-3 بهدست نیامد (07/0P=).
نتیجهگیری: بهنظر میرسد که مداخله ده هفته ورزش هوازی متعاقب چهار هفته بعد از انفارکتوس قلبی موشها، اختلالات عملکرد بطن چپ را کاهش میدهد و در نتیجه منجر به بهبود کارآیی سیستولیک بطن چپ، کاهش اندازه ناحیه انفارکتوس و نرخ مرگ و میر میشود.
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