Effect of 10 Weeks Aerobic Exercise Training on Left Ventricular Systolic Function, Caspase-3 Level and Infarction Size in Myocardial Infarction Rat
DOI:
https://doi.org/10.22100/jkh.v10i3.680Keywords:
Exercise training, Ejection fraction, Fractional shortening, Myocardial infarction.Abstract
Introduction: The aim of study was to evaluate the effect of 10 weeks aerobic exercise training on left ventricular systolic function, caspase-3level and infarction size in myocardial infarction rats.
Methods: Four weeks after the myocardial infarction, 30 male Wistar rats were randomized to the three equally sized groups of Sham-operated control (Sham); Sedentary-MI (SedMI) and Exercise-MI (ExMI).The latest group were subjected to aerobic training in the form of treadmill running (50 min/day, 5 times per week, 17 m/min). Before and after the training program, all subjects went under echocardiography.
Results: Statistical analysis of the data showed that the rate of ejection fraction and the fractional shortening at 4 and 14 weeks after myocardial infarction decreased significantly in SedMI and ExMI compared to the Sham group (P<0.05). But the rate of ejection fraction and fractional shortening at 14 weeks after myocardial infarction in ExMI group was significantly greater than SedMI group (P<0.05). Also, infarction size and mortality rate decreased significantly in response to exercise training but the caspase-3 activity was not different between groups.
Conclusion: 10-weeks aerobic exercise training program, 4 weeks after myocardial infarction, reduced cardiac dysfunctions after myocardial infarction in trained rats. Consequently, these exercise training induced changes resulted in improved left ventricular systolic function and decrease of mortality rate and infarction size after myocardial infarction.
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