بررسی تأثیر اختلال در ریتم شبانه‌روزی بر اثربخشی درمان با متفورمین در بافت کبد و فعالیت آنزیم‌های کبدی در موش‌های صحرایی دیابتی

Fagiani F, Di Marino D, Romagnoli A, Travelli C, Voltan D, Di Cesare Mannelli L, et al. Molecular regulations of circadian rhythm and implications for physiology and diseases. Signal Transduct Target Ther 2022;7:41. doi: 10.1038/s41392-022-00899-y

Thakur A, Kishore R. Neurobiology of the circadian clock and its role in cardiovascular disease: Mechanisms, biomarkers, and chronotherapy. Neurobiol Sleep Circadian Rhythms 2025;19:100131. doi: 10.1016/j.nbscr.2025.100131

Baek JH, Zhu Y, Jackson CL, Park YM. Artificial Light at Night and Type 2 Diabetes Mellitus. Diabetes & Metabolism Journal 2024;48:847-63. doi: 10.4093/dmj.2024.0237

Mukherji A, Bailey SM, Staels B, Baumert TF. The circadian clock and liver function in health and disease. Journal of Hepatology 2019;71:200-11. doi: 10.1016/j.jhep.2019.03.020

Antar SA, Ashour NA, Sharaky M, Khattab M, Ashour NA, Zaid RT, et al. Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments. Biomedicine & Pharmacotherapy 2023;168:115734. doi: 10.1016/j.biopha.2023.115734

Mohamed J, Nazratun Nafizah AH, Zariyantey AH, Budin SB. Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation. Sultan Qaboos University Medical Journal 2016;16:e132-41. doi: 10.18295/squmj.2016.16.02.002

Coomans CP, van den Berg SA, Lucassen EA, Houben T, Pronk AC, van der Spek RD, et al. The suprachiasmatic nucleus controls circadian energy metabolism and hepatic insulin sensitivity. Diabetes 2013;62:1102-8. doi: 10.2337/db12-0507

Radziuk JM. The suprachiasmatic nucleus, circadian clocks, and the liver. Diabetes 2013;62:1017-9. doi: 10.2337/db12-1765

Rena G, Hardie DG, Pearson ER. The mechanisms of action of metformin. Diabetologia 2017;60:1577-85. doi: 10.1007/s00125-017-4342-z

Dumortier G, Cabaret W, Stamatiadis L, Saba G, Benadhira R, Rocamora JF, et al. Hepatic tolerance of atypical antipsychotic drugs. L'Encephale 2002;28:542-51.

Mohseni F, Vahedifar A, Garmabi K, Bakhtazad A, Garmabi B. Impact of circadian disruption on cart mrna expression in nucleus accumbent: insights from constant light exposure and wheel-running activity in rats. Shahroud Journal of Medical Sciences 2025;11:8-16. doi‎: 10.32598/bcn.2022.1425.6

Tahara Y, Shibata S. Circadian rhythms of liver physiology and disease: experimental and clinical evidence. Nature reviews Gastroenterology & Hepatology 2016;13:217-26. doi: 10.1038/nrgastro.2016.8

Akhtar RA, Reddy AB, Maywood ES, Clayton JD, King VM, Smith AG, et al. Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Current Biology: CB 2002;12:540-50. doi: 10.1016/s0960-9822(02)00759-5

Forsyth CB, Voigt RM, Burgess HJ, Swanson GR, Keshavarzian A. Circadian rhythms, alcohol and gut interactions. Alcohol 2015;49:389-98. doi: 10.1016/j.alcohol.2014.07.021

Dallmann R, Brown SA, Gachon F. Chronopharmacology: new insights and therapeutic implications. Annual Review of Pharmacology and Toxicology 2014;54:339-61. doi: 10.1146/annurev-pharmtox-011613-135923

Festus ID, Spilberg J, Young ME, Cain S, Khoshnevis S, Smolensky MH, et al. Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health. Trends in Endocrinology and Metabolism: TEM 2024;35:607-23. doi: 10.1016/j.tem.2024.02.011

Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, et al. Drug-induced liver injury. Nature Reviews Disease Primers 2019;5:58. doi: 10.1038/s41572-019-0105-0

Meng X-M, Ma X-X, Tian Y-L, Jiang Q, Wang L-L, Shi R, et al. Metformin improves the glucose and lipid metabolism via influencing the level of serum total bile acids in rats with streptozotocin-induced type 2 diabetes mellitus. Eur Rev Med Pharmacol Sci 2017;21:2232-7. doi: 10.26355/eurrev_201709_15810

Wang F, Zhang L, Wu S, Li W, Sun M, Feng W, et al. Night shift work and abnormal liver function: is non-alcohol fatty liver a necessary mediator? Occupational and Environmental Medicine 2019;76:83-9. doi: 10.1136/oemed-2018-105273

Mohammadi M, Tabari M, Tavakolipor H, Mohammadi S. The effect of Allium saralicum R. M. Fritsch nanocapsules in yogurt on type 2 diabetes in male rats: physicochemical characterization and pharmacodynamics assessment. 3 Biotech 2023;13:222. doi: 10.1007/s13205-023-03589-w

Viollet B, Guigas B, Sanz Garcia N, Leclerc J, Foretz M, Andreelli F. Cellular and molecular mechanisms of metformin: an overview. Clinical Science 2012;122:253-70. doi: 10.1042/CS20110386

Foretz M, Hébrard S, Leclerc J, Zarrinpashneh E, Soty M, Mithieux G, et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. The Journal of Clinical Investigation 2010;120:2355-69. doi: 10.1172/JCI40671

Foretz M, Guigas B, Bertrand L, Pollak M, Viollet B. Metformin: from mechanisms of action to therapies. Cell Metabolism 2014;20:953-66. doi: 10.1016/j.cmet.2014.09.018