Investigating the Percentage of Th1 lymphocytes in Peripheral Blood of Patients with Autosomal Recessive Hyper-IgE Syndrome

Authors

  • Arezou Rahimi1 1- Dept. of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Zahra Chavoshzad2 2- Dept. of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Nima Rezaei3 3- Dept. of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Mahboubeh Mansouri2
  • Delara Babaie4 4- Dept. of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohammad Nabavi5 5- Dept. of Allergy and Clinical Immunology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Hamid Farajifard6 6- Dept. of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Amir Atashi7 7- Stem Cell and Tissue Engineering Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Mehrdad Amirmoini8 8- Dept. of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Razeye Rezaei9 9- Dept. of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Reza Alimohammadi10 10- Dept. of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mehrnaz Mesdaghi4

DOI:

https://doi.org/10.22100/jkh.v11i4.1577

Keywords:

Autosomal recessive, hyper-IgE Syndrome, IFN-γ, Th1

Abstract

Introduction: Hyper-IgE syndrome is a primary immunodeficiency disease, characterized by increased susceptibility to a limited range of fungal and bacterial infections, especially Candida Albicans and Staphylococcus Aureus. The study of different subtypes of lymphocytes would be helpful in understanding of the disease pathogenesis. In this study, the percentage of Th1 lymphocytes in peripheral blood of patients with autosomal recessive hyper-IgE syndrome was investigated.

Methods: In this case-control study, six patients with autosomal recessive hyper IgE syndrome and seven healthy controls, which were age and sex matched, were studied. Peripheral blood mononuclear cells were isolated from venous blood. After cell stimulation and culture for 12 hours, the percentage of Th1 cells was evaluated by flow cytometry.

Results: The results of this study showed that the percentage of Th1 cells was significantly decreased in patients compared to the control group (P<0.005).

Conclusion: The reduction in Th1 lymphocytes may play an important role in the pathogenesis of autosomal recessive hyper-IgE syndrome and their increased susceptibility to bacterial and fungal infections.

Author Biography

  • Nima Rezaei3, 3- Dept. of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

    گروه ایمونولوژی و آلرژی، بیمارستان کودکان مفید، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران

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Published

2017-02-05

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Vol 11, No 4: 2017

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Original Article(s)

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How to Cite

Investigating the Percentage of Th1 lymphocytes in Peripheral Blood of Patients with Autosomal Recessive Hyper-IgE Syndrome. (2017). Knowledge and Health in Basic Medical Sciences, 11(4), page:56-62. https://doi.org/10.22100/jkh.v11i4.1577

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