Relation of Total Antioxidant Capacity with Static Volumes as Lung Function in Adult Males with Chronic Asthma
DOI:
https://doi.org/10.22100/jkh.v12i2.1652Keywords:
Asthma, Total antioxidant capacity, Lung function, Spirometry.Abstract
Introduction: Recent evidence has shown that the asthma patients have lower antioxidant capacity (TAC) than healthy individuals. However, little information on the influence of TAC on lung function is available in these patients. This study aimed to determine relation of TAC with Spirometric markers in these patients.
Methods: For this purpose, thirty sedentary adult males with mild to moderate asthma aged 40 ± 7 years were enrolled to study by targeted sampling. Fasting blood samples were collected with regard to measuring TAC of all patients. Anthropometric and spirometry markers (FVC, FEV1, FEV1/FVC) were also measured in all patients. Data from TAC and other variables were analyzed by Pearson correlation.
Results: Data showed that TAC was positively correlated with FVC (P=0.036, r=0.48), FEV1 (P=0.002, r=0.73) and FEV1/FVc (P=0.001, r=0.77) in studied patients.
Conclusion: Based on these data, it is concluded that TAC is a suitable marker for predict lung function and disease intensity in males with asthma.
References
Armstrong N, Van Mechelen W. Pediatric exercise science and medicine. London: Oxford University Press. 2013. 323-328.
Shore SA. Obesity and asthma: implications for treatment. Curr Opin Pulm Med. 2007 Jan; 13(1):56-62.
Hilda Segura N, Hernández L, Velázquez C, Rodríguez J, Murillo E. Asthma and obesity: related inflammatory diseases. Rev Alerg Mex. 2007 Jan-Feb; 54(1):24-8.
Ma J, Xiao L, Knowles SB. Obesity, insulin resistance and the prevalence of atopy and asthma in US adults.Allergy. 2010; 65(11):1455-63.
Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004; 59(5): 469-78.
Katsoulis K, Kontakiotis T, Leonardopoulos I, Kotsovili A, Legakis IN, Patakas D. Serum total antioxidant status in severe exacerbation of asthma: correlation with the severity of the disease. J Asthma. 2003 Dec; 40(8):847-54.
Yoon SY, Kim TB, Baek S, Kim S, Kwon HS, Lee YS et al. The impact of total antioxidant capacity on pulmonary function in asthma patients. Int J Tuberc Lung Dis. 2012 Nov; 16(11):1544-50.
Urso ML, Clarkson PM. Oxidative stress, exercise and antioxidant supplementation. Toxinology. 2003; 189: 41-54.
Wellman KF, Bloomer RJ. Acute exercise and oxidative stress: a 30 year history. Dynamic Medicine. 2009; 8: 1-25.
Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem. 1996; 239(1): 70-76.
Comhair SA, Xu W, Ghosh S, Thunnissen FB, Almasan A, Calhoun WJ, et al. Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity. Am J Pathol. 2005; 166(3): 663-74.
Fujisawa T. Role of oxygen radicals on bronchial asthma. Curr Drug Targets Inflamm Allergy. 2005 Aug; 4(4): 505-9.
Marcal LE, Rehder J, Newburger PE, Condino-Neto A. Superoxide release and cellular gluthatione peroxidase activity in leukocytes from children with persistent asthma. Braz J Med Biol Res. 2004; 37(11): 1607-13.
Kolarzyk E, Pietrzycka A, Kaczyńska-Ratka A, Skop-Lewandowska A. Diet with high antioxidant capacity as important factor in primary and secondary prevention of asthma. Przegl Lek. 2015; 72(12): 743-6.
Fatani SH .Biomarkers of oxidative stress in acute and chronic bronchial asthma. J Asthma. 2014 Aug; 51(6): 578-84.
Ahmad A, Shameem M, Husain Q. Relation of oxidant-antioxidant imbalance with disease progression in patients with asthma. Ann Thorac Med. 2012 Oct; 7(4): 226-32.
Calhoun WJ, Reed HE, Moest DR, Stevens CA. Enhanced superoxide production by alveolar macrophages and air-space cells, airway inflammation, and alveolar macrophage density changes after segmental antigen bronchoprovocation in allergic subjects. Am Rev Respir Dis. 1992; 145: 317–325.
Comhair SA, Erzurum SC. Redox control of asthma: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal. 2010; 12: 93–124.
MacPherson JC, Comhair SA, Erzurum SC, Klein DF, Lipscomb MF, Kavuru MS, et al. Eosinophils are a major source of nitric oxidederived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species. J Immunol. 2001; 166(9): 5763-72.
Barnes PJ. Reactive oxygen species and airway inflammation. Free Radic Biol Med 1990; 9(3): 235-43.
Comhair SA, Xu W, Ghosh S, Thunnissen FB, Almasan A, Calhoun WJ, et al. Superoxide dismutase inactivation in pathophysiology ofasthmatic airway remodeling and reactivity. Am J Pathol 2005; 166(3): 663-74.
Fabian E, Pölöskey P, Kósa L, Elmadfa I, Réthy LA. Activities of antioxidant enzymes in relation to oxidative and nitrosative challenges in childhood asthma. J Asthma. 2011 May; 48(4): 351-7.
Rodríguez-Rodríguez E, Ortega RM, González-Rodríguez LG, Peñas-Ruiz C, Rodríguez-Rodríguez P. Dietary total antioxidant capacity and current asthma in Spanish schoolchildren: a case control-control study. Eur J Pediatr. 2014 Apr; 173(4): 517-23.
Samet JM, Hatch GE, Horstman D, Steck-Scott S, Arab L, Bromberg PA et al. Effect of Antioxidant Supplementation on Ozone-Induced Lung Injury in Human Subjects. Am J Respir Crit Care Med. 2001 Sep 1; 164(5): 819-25.
Horstman DH, Folinsbee LJ, Ives PJ, Abdul-Salaam S, McDonnell WF. Ozone concentration and pulmonary response relationships for 6.6-h exposures with 5 hr of moderate exercise to 0.08, 0.10 and 0.12 ppm. Am Rev Respir Dis 1990; 142: 1158–1163.
Onur E, Kabaroğlu C, Günay O, Var A, Yilmaz O, Dündar P et al. The beneficial effects of physical exercise on antioxidant status in asthmatic children. Allergol Immunopathol (Madr). 2011; 39(2):90-95.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
