High-Intensity Interval Training Through mTOR and SREBP1 Proteins Leads to the Regulation of Adipose Tissue in Rats Obese with Type 2 Diabetes

Abstract

Introduction: The mTOR and SREBP1 proteins are key proteins in the metabolism and adipose tissue regulation. Obesity and type 2 diabetes can disorder with the function of these two proteins. The purpose of the present study was to investigate the effect of high-intensity interval training on the content of mTOR and SREBP1 proteins in subcutaneous fat tissue in obese type 2 diabetic male Sprague-Dawley rats with diabetes.

Methods: In this experimental study, 16 two-month-old Sprague-Dawley rats with a mean weight of 300±20 g were selected. After diabetic induction with STZ and Nicotinamide, rats were randomly assigned to two groups, diabetic training (8 heads) and diabetic control (8 heads). The training group trained HIIT for 4 days a week in accordance with the training program for 8 weeks, while the control group did not have any training program. The independent t-test was used to analyze the data.

Results: There was a significant increase in the content of mTOR (P=0.001) and SREBP1 (P=0.001) proteins in the training group compared to control; The control group weight (P=0.001) and training group (P=0.009) significantly increased at the end of the eighth week compared to the first week; Also, blood glucose levels in the control group showed a significant increase in the 8th week compared to the first week (P=0.001). But in the training group at the end of the eighth week, it was lower than the first week (P=0.001).

Conclusion: Endurance training can adjust the weight, blood glucose and proteins content of mTOR and SREBP1; therefore, the HIIT exercise can be a good way to regulate metabolism and adipose tissue.