The Effect of Three Types of Resistance Training, Aerobic, Combined on Serum Levels of Growth Differentiating Factor (GDF-15) in Active Elderly Men

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DOI:

https://doi.org/10.22100/jkh.v17i4.2469

Abstract

Introduction: Growth differentiation factor-15 (GDF-15) is a marker of inflammation, oxidative stress and it is associated with adverse prognosis in cardiovascular disease. GDF-15 as a predictor for various types of cardiovascular diseases such as heart failure, are affected by training and sports activity. The effect of eight weeks of resistance, aerobic, and combined training on the salivary levels of GDF-15  in active older men was investigated.

Methods: The 36 cases were randomly divided into three groups of 12 (1. resistance training, 2. aerobic training, and 3. combined training). The serum GDF-15 salivary value in cases was estimated and recorded using a sandwich ELISA by special kits. After eight weeks of training protocols the data were analyzed by paired t-test and Scheffe post hoc test to examine the differences between groups by SPSS software.

Results: The results showed that the amount of salivary GDF-15 significantly increased after aerobic exercise by 6.4%, decreased after resistance training by 18.05%, and was unchanged after combination training.

Conclusion: Based on our findings, surprisingly, resistance exercise had a positive and significant effect on enhancing risk factors and reducing the salivary levels of GDF-15.

Author Biography

  • حسن نوری نژاد, - Dept. of Professional Physical Education And Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.

    گروه تربیت بدنی و علوم ورزشی

    استادیار

References

Jerome L. Fleg. Aerobic Exercise in the Elderly: A Key to Successful Aging. Specialty: Aging, ‎Cardiology. Institution: Division of Cardiovascular Sciences. National Heart. Lung, and ‎Blood Institute, National Institutes of Health. Address,2018;6701-20892.

Malekshahi Nia H, Dehkhoda M, Ahangarpour A, Rajabi H, The effect of 6 weeks of continuous aerobic exercise on insulin resistance, nitric oxide and some lipid profiles of diabetic male rats. Jundishapur Scientific Medical Journal 2018;17:4. doi: 10.22118/JSMJ.2018.158583.1530

Fábio S, Lira G, Pimentel D, Ronaldo VT. Exercise training improves sleep pattern ‎and metabolic profile in elderly people in a time-dependent manner. Lipids Health 2011;10: ‎‎113-124. doi: 10.1186/1476-511X-10-113

SonuPunia, Sivachidambaram K,Varun S. Effect of Aerobic Exercise Training on ‎Blood Pressure in Indians: Systematic Review. International Journal of Chronic Diseases 2016;1370148:8. doi: 10.1155/2016/1370148

Fadavi-Ghaffari M, Azad A, Meimandi M, Arani-Kashani Z, Gorbanpoor H, The psychometric properties of falls efficacy scale in the elderly Iranian resident of nursing homes. Iranian Rehabilitation Journal 2019;17:197-206. doi: 10.32598/irj.17.3.197

Abete, P., Testa, G., Della-Morte, D., Gargiulo, G., Galizia, G., De Santis, D., Cacciatore, F. Treatment for chronic heart failure in the elderly: current practice and problems. Heart Failure Reviews 2013; 18:529-51. doi:10.1007/s10741-012-9363-6

Viviane M, Paul B, Johan V, Manuella M, Viviane VH, Cathe´rine De M, Nadine P, Floris L, Christiaan J, Combined endurance/resistance training reduces NT-proBNP levels in patients with chronic heart failure. Clinical research. European Heart Journal 2004;25:1797-805. doi: 10.1016/j.ehj.2004.07.022

Rangers E, Mirzaei B, Rahmaninia F. The effect of resistance training on serum levels of high sensitivity troponin I and GDF-15 in elderly men. Journal of Health Promotion Management 2019;6. doi: 10.22049/JAHSSP.2022.27711.1449

Hofmann M, Halper B, Oesen S, Franzke B, Stuparits P, Tschan H, et al. Serum concentrations of insulin-like growth factor-1, members of the TGF-beta superfamily and follistatin do not reflect different stages of dynapenia and sarcopenia in elderly women. Experimental Gerontology 2015;64:35-45. doi: 10.1016/j.exger.2015.02.008

ShanhuiXie, Liping Lu, Liwei L. Growth differentiation factor-15 and the risk of cardiovascular diseases and all-cause mortality: A meta-analysis of prospective studies. Clinical Cardiology Wiley 2019;42:513-23. doi: 10.1002/clc.23159

Lok DJ, Klip IT, Lok SI, Badings E, van Wijngaarden J, Voors AA, et al. Incremental prognostic power of novel biomarkers (growth-differentiation factor-15, high-sensitivity C-reactive protein, galectin-3, and high-sensitivity troponin-T) in patients with advanced chronic heart failure. The American Journal of Cardiology 2013;112:831-7. doi: 10.1016/j.amjcard.2013.05.013

Ding Q, Mracek T, Gonzalez-Muniesa P, Kos K, Wilding J, Trayhurn P, et al. Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology 2009;150:1688-96. doi: 10.1210/en.2008-0952

Jurczyluk J, Brown D, Stanley K, Polarised secretion of cytokines in primary human microvascular endothelial cells is not dependent on N-linked glycosylation. Cell Biology International 2003;27:997-1003. doi:10/1016/j.cellbi.2003.09.002

Kempf T, Eden M, Strelau J, Naguib M, Willenbockel C, Tongers J, et al. The transforming growth factor-β superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circulation Research 2016; 98:351-60. doi: 10.1161/01.RES.0000202805.73038.48

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Published

2023-01-08

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The Effect of Three Types of Resistance Training, Aerobic, Combined on Serum Levels of Growth Differentiating Factor (GDF-15) in Active Elderly Men. (2023). Knowledge and Health in Basic Medical Sciences, 17(4), Page:44-49. https://doi.org/10.22100/jkh.v17i4.2469

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