Candidemia in Burn Patients: Epidemiology and Molecular Typing of Candida Isolates
Authors
-
Seyed Reza Aghili
- Invasive Fungi Research Center, Communicable Diseases Institute/, Mazandaran University of Medical Sciences, Sari, Iran.
https://orcid.org/0000-0001-9469-0054
-
Tahereh Shokohi
- Dept. of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
https://orcid.org/0000-0003-3094-8436
- Bahram Salari - Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
-
Seyedeh Zahra Noorani Baladezaei
- Antimicrobial Resistance Research Center, Dept. of Infectious Diseases, Mazandaran University of Medical Sciences, Sari, Iran.
https://orcid.org/0000-0002-4622-1699
- Mostafa Roudbari - Dept. of Laboratory Medicine, Faculty of Allied Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
-
Leila Faeli
- Dept. of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
https://orcid.org/0000-0002-9479-0255
-
Iman Haghani
- Invasive Fungi Research Center, Communicable Diseases Institute/, Mazandaran University of Medical Sciences, Sari, Iran. - Dept. of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
https://orcid.org/0000-0001-9723-7618
-
Sabah Mayahi
- Dept. of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
https://orcid.org/0000-0002-9264-8984
DOI:
https://doi.org/10.22100/jkh.v19i2.3106Keywords:
Candidiasis, Candidemia, Burn, Species identification, Molecular methodAbstract
Introduction: Candidemia is a major hospital-acquired fungal infection, especially among burn patients. Recognizing the risk factors and the particular organism involved is crucial for effective treatment.
Methods: Blood samples from 147 hospitalized burn patients were collected, totaling 534 samples, and cultured in a biphasic medium, then incubated aerobically at 37°C. Candida species were identified using specialized culture media and RFLP-PCR with the MspI restriction enzyme. Descriptive statistics were applied to outline the risk factors, while Student's t-test was employed to compare the variables.
Results: Candidemia was detected in 8 patients (5.44%) among hospitalized burn patients. The mean age was 38.3±21.3 years, with an average hospital stay of 32.7 days, a total body surface area burned of 32.7%, and a mortality rate of 19.7%. Patients with candidemia had higher values for these variables.
Conclusion: The rapid identification, effective management, and treatment of this infection can significantly decrease complications and mortality rates in patients with burn injuries.
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