Role of Progesterone Administration on Endometrial Angiogenesis and other Endometrial Quantative Changes in Hyperstimulated Mice at Implantation Period

Authors

  • Sedigheh Momeni1 Dept. of Biology, School of Sciences, Arak University, Arak, Iran
  • Mandana Beigi Boroujeni2 Dept. of Anatomy, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Hamid Reza Momeni3 Dept. of Biology, School of Sciences, Arak University, Arak, Iran.
  • Nasim Beigi Boroujeni4 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Ezatollah Rafiee Alavi5 Dept. of Pathology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Mohamad Reza Gholami6 Dept. of Anatomy, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

DOI:

https://doi.org/10.22100/jkh.v10i4.848

Keywords:

آندومتر، پروژسترون، تعداد مقطع عروق،تغییرات کمی اندومتر،زمان لانه گزینی

Abstract

Introduction: The vascular parameters changes from the morphological aspects resulted in changes in the rate of the embryo implantation. This event depend on theovarian hormones. In this study, the quantiative changes of the endometrium was assessed after ovarian stimulation followed by progesterone (p4) treatment.

Methods: Adult female mice were used in this study. Animals were divided in three groups. pseudopregnancy were induced in the control group. Then in the experimental group1 (ovarian induction group)and experimental group2(p4 treated after ovarian induction), ovarian stimulation was done. P4 treatment was done daily in the experimental group2 after pseudopregnancy. Finally, blood and tissue samples were taken for assessment of the ovarian hormone levels and histogical studies, respectively. Then statistical analysis was done.

Results: The results indicated the significant increase in the progesterone level, vascular sections, internal area of vessels, and the diagonal of the glandular lumen in two experimental groups (1&2) compared to the control group (P≤0.05). Also, P4 treatment after ovarian induction resulted in the significant increase in the P4 level and vascular section number in the experimental group 2 compared to the experimental group1 (P≤0.05).

Conclusion: P4 treatment after ovarian induction improve the morphological condition of the endomertium compared to the ovarian induction group. Therefore, it may result in an increased rate of successful implantation.

Author Biographies

  • Sedigheh Momeni1, Dept. of Biology, School of Sciences, Arak University, Arak, Iran

    فوق لیسانس فیزیولوژی جانوری گروه زیست شناسی

  • Mandana Beigi Boroujeni2, Dept. of Anatomy, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

    استادیار گروه اناتومی

  • Hamid Reza Momeni3, Dept. of Biology, School of Sciences, Arak University, Arak, Iran.

    گروه زیست شناسی. استادیار

  • Nasim Beigi Boroujeni4, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
    استادیار دانشگاه علوم پزشکی لرستن
  • Ezatollah Rafiee Alavi5, Dept. of Pathology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
    استادیار گروه پاتولوژی
  • Mohamad Reza Gholami6, Dept. of Anatomy, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

    استادیار گروه اناتومی

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Published

2015-09-28

Issue

Vol 10, No 4: 2016

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Original Article(s)

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How to Cite

Role of Progesterone Administration on Endometrial Angiogenesis and other Endometrial Quantative Changes in Hyperstimulated Mice at Implantation Period. (2015). Knowledge and Health in Basic Medical Sciences, 10(4), Page:31-39. https://doi.org/10.22100/jkh.v10i4.848

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