Predictors of Quality of Life in Patients with Epilepsy
DOI:
https://doi.org/10.22100/jkh.v10i1.534Keywords:
Epilepsy, Quality of life, Seizure, PatientsAbstract
Introduction: Quality of life among patients with epilepsy is severely affected by consequences of physical, psychological, social of epilepsy. The aim of present study was to evaluate predictors of quality of life in epileptic patients and to determine the main effective factors.
Methods: This is a comparative cross sectional study on 100 epileptic patients and 100 healthy people from patient's relatives who referred to neurology clinic of 22 Bahman hospital in Mashhad. Data were collected through the WHO quality of life (QOL) standard questionnaire. Multiple linear regression analysis was used to determine predictor factors of quality of life in patients with epilepsy.
Results: The mean total score of quality of life in two groups of patients and healthy people showed no significant difference. Only in the physical (P<0.001), environment (P=0.002) and social domain (P<0.001) differences were statistically significant. Multiple linear regression analysis showed that age, sex, education level, type of epilepsy, and numbers of seizures in one month are effective factors. In all four domains of QOL, quality of life score decreased by increasing the episodes of seizures. Moreover, females compared with males had higher quality of life scores.
Conclusion: Age, sex, education level, type of epilepsy, and number of seizures were important predictors of total QOL in patients with epilepsy. Number of seizures and female gender had higher effect on QOL. Based on our findings controlling numbers of seizures is the key factor in improving the quality of life among patients with epilepsy.
References
Katzung BG, Masters SB, Trevor AJ. Basic & clinical pharmacology.10th ed. LANGE: McGraw Hill Medical;2007.
Chang BS, Lowenstein DH. Epilepsy. NEJM 2003;349:1257-66.
Simon RP, Greenberg DA, Aminoff MJ. Clinical neurology. 7th ed. New York, NY: McGraw-Hill Professional;2009.
Magalov SI, Hasanov NF, Azizova NX, Novruzov AN, Mustafayev ZB, Kazimov SA, et al. The prevalence of epilepsy in the nakhichevan autonomous republic of Azerbaijan. CNS & Neurological Disorders-Drug Targets 2012;11:102-9.
Banerjee PN, Hauser WA. Incidence and prevalence. In: Engel J, Pedley TA, editors. Epilepsy: a comprehensive textbook. Philadelphia: Lippincott Raven pub;2008.p.47-57.
Forsgren L, Beghi E, Oun A, Sillanpaa M. The epidemiology of epilepsy in Europe - a systematic review. European Journal of Neurology 2005;12: 245-53.
Gharegozli K, Kolahi A, Bolhari J, Zaman G, Keyhanidoost Z, Poortaherian P. Public knowledge and attitudes toward epilepsy in Tehran. Tehran Univ Med J 2006;64:22-30.[Persian].
Mohammadi MR, Ghanizadeh A, Davidian H, Mohammadi M, Norouzian M. Prevalence of epilepsy and comorbidity of psychiatric disorders in Iran. Seizure 2006;15:476-82.
Stephen LJ, Brodie MJ. Epilepsy in elderly people. Lancet 2000; 8:1019-30.
Browne TR, Holmes GL. Management. In: Browne TR, Holmes GL, editors. Handbook of epilepsy. 4th ed. Philadelphia: Lippincott Williams and Wilkins;2008.p.151-75.
Wyllie E, Cascino GD, Gidal BE, Goodkin HP. Wyllie's treatment of epilepsy: principles and practice. 5th ed.Philadelphia: Williams & Wilkins, Lippincott;2010.
Rowan AJ, Ramsay RE, Collins JF, Pryor F, Boardman KD, Uthman BM, et al. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology 2005;64:1868-73.
Norris J, Bladin C, Johnston P, Alexandrov A, Smurawska L. The occurrence of seizures after stroke. Neurology 1994;44:A327.
Beattie PE, Lewis-Jones MS. A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases. The British Journal of Dermatology 2006;155:145-51.
Kanner AM. Depression and epilepsy: a new perspective on two closely related disorders. Epilepsy Currents / American Epilepsy Society 2006;6:141-6.
Hills M. The psychological and social impact of epilepsy. Neurology Asia 2007;12:10-2.
Jacoby A, Snape D, Baker GA. Determinants of quality of life in people with epilepsy. Neurologic Clinics 2009;27:843-63.
Schachter SC. Quality of life for patients with epilepsy is determined by more than seizure control: the role of psychosocial factors. Expert Review of Neurotherapeutics 2006;6:111-8.
Leidy NK, Elixhauser A, Vickrey B, Means E, Willian MK. Seizure frequency and the health-related quality of life of adults with epilepsy. Neurology 1999;53:162-6.
Mrabet H, Mrabet A, Zouari B, Ghachem R. Health-related quality of life of people with epilepsy compared with a general reference population: a Tunisian study. Epilepsia 2004;45:838-43.
Choi-Kwon S, Chung C, Kim H, Lee S, Yoon S, Kho H, et al. Factors affecting the quality of life in patients with epilepsy in Seoul, South Korea. Acta Neurologica Scandinavica 2003; 108:428-34.
Liou HH, Chen RC, Chen CC, Chiu MJ, Chang YY, Wang JD. Health related quality of life in adult patients with epilepsy compared with a general reference population in Taiwan. Epilepsy Research 2005;64:151-9.
Yue L, Yu PM, Zhao DH, Wu DY, Zhu GX, Wu XY, et al. Determinants of quality of life in people with epilepsy and their gender differences. Epilepsy & Behavior 2011;22:692-6.
Djibuti M, Shakarishvili R. Influence of clinical, demographic, and socioeconomic variables on quality of life in patients with epilepsy: findings from Georgian study. Journal of Neurology, Neurosurgery, and Psychiatry 2003;74:570-3.
Nejat S, Montazeri A, Holakouie Naieni K, Mohammad K, Majdzadeh SR. The world health organization quality of life (WHOQOL-BREF) questionnaire: Translation and validation study of the Iranian version. SJSPH 2006;4:1-12.[Persian].
Shaafi S, Hashemilar M, Nikanfar M, Savadi Oskoue D, Tavakoli S. A study of the quality of life in the epileptic patients. Iranian Journal of Neurology 2007;6:106-12.
Thomas SV, Koshy S, Nair CR, Sarma SP. Frequent seizures and polytherapy can impair quality of life in persons with epilepsy. Neurol India 2005;53:46-50.
Darabi L, Montazeri A, Ebrahimi F, Vahdaninia M, Togha M. Clinical and demographic characteristics and quality of life in patients with epilepsy. Payesh 2010;9:215-21.[Persian].
Baker GA, Jacoby A, Gorry J, Doughty J, Ellina V, For the SIGN Group. Quality of life of people with epilepsy in Iran, the Gulf, and Near East. Epilepsia 2005;46:132-40.
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