Investigation of the Effect of Cardiac Rehabilitation Program on Peripheral Blood Mononuclear Cells ABCA1 Gene Expression in Myocardial Infractions Patient

Authors

  • Alireza Hajighasemi1 1- Dept. of Exercise Physiology, Alborz campus, Tehran University, Tehran, Iran.
  • Ali Asghar Ravasi2 2- Dept. of Exercise Physiology, College of Physical Education and Sport Sciences, Tehran University, Tehran, Iran.
  • Mohamadreza Kordi3 3- Dept. of Exercise Physiology, College of Physical Education and Sport Sciences, Tehran University, Tehran, Iran.
  • Amir Rashidlamir4 4- Dept. of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran.
  • Akhtar Ghorghi5 5- Dept. of Exercise Physiology, Shahrood University, Shahrood, Iran.

DOI:

https://doi.org/10.22100/jkh.v11i4.1523

Keywords:

Moderate resistance training, ABCA1 gene, Reverse cholesterol transport

Abstract

Introduction: Atherosclerotic heart disease is a major important cause of mortality in most countries. ABCA1 transporter is responsible for making and forming of HDL particles and therefore probably plays a crucial role in prevention of atherosclerosis. The purpose of this study was to assess the effect of rehabilitation training on ABCA1 gene expression of peripheral blood mononuclear cells (PBMN).

Methods: Twenty three myocardial infractions patients were randomly selected and assigned into two groups; control (N=11) and experimental (N=12). Moderate resistance training was conducted by experimental group for 60 minutes at three sessions for eight weeks with 40-60% of one repetition maximum (1RM). Blood sample of subjects were collected before and after training. PBMN cells were separated and m-RNA purification was performed by real–time PCR. Data was analyzed by ANCOVA in SPSS software (significant leve equal 0.05).

Results: Results showed that expression of PBMN ABCA1 m-RNA was significantly increased with moderate resistance training in myocardial infractions patient group. There was no significant differences in mean of HDL-C, LDL-C (P>0.05).

Conclusion: As result that moderate resistance training increases the expression of ABCA1 gene on PBMN cells of MI patient, improves the function of reverse cholesterol transfer, and probably prevents repetition of Ischemic.

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Published

2017-02-05

Issue

Section

Original Article(s)

How to Cite

Investigation of the Effect of Cardiac Rehabilitation Program on Peripheral Blood Mononuclear Cells ABCA1 Gene Expression in Myocardial Infractions Patient. (2017). Knowledge and Health in Basic Medical Sciences, 11(4), page:23-29. https://doi.org/10.22100/jkh.v11i4.1523

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