The Combined Effect of Endurance Training and Atorvastatin on Serum Interleukin-10 Levels Following Experimental Myocardial Infarction in Rats

Authors

  • Akbar Azamian Jazi1 1- Dept. of Physical Education & Sports Sciences, Faculty of Letters and Humanities, Shahrekord University, Shahrekord, Iran.
  • Iraj Ahmadi2 2- Dept. of Physical Education & Sports Sciences, Faculty of Letters and Humanities, Shahrekord University, Shahrekord, Iran.
  • Ali Shafizadeh3 3- Dept. of Physical Education & Sports Sciences, Faculty of Letters and Humanities, Shahrekord University, Shahrekord, Iran.
  • Mohammad Reza Hafezi4 4. Dept. of Pathobiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

DOI:

https://doi.org/10.22100/jkh.v11i4.1532

Keywords:

Endurance exercise training, Atorvastatin, Interleukin-10, Myocardial infarction, Rat

Abstract

Introduction: Atorvastatin and endurance training (ET) may have synergic positive effects on inflammation process, following myocardial infarction (MI). Therefore, the present study aimed to investigate the combined effect of endurance training and three doses of atorvastatin on serum interleukin-10 (IL-10) levels following experimental myocardial infarction in rats.

Methods: 75 rats (age 8-10 weeks and 230±10 g body weight) were randomly divided to 9 groups. Sham, control, endurance training, atorvastatin (5, 10 and 15 mg/kg), and exercise plus atorvastatin (5, 10 and 15 mg/kg). MI was induced by subcutaneous injection of isoprenaline (150 mg/kg) in two consecutive days. Drug and training intervention was initiated 2 days after MI and continued for 4 weeks. Data were analyzed by using one-way analyses of variance (ANOVA) at P<0.05 level.

Results: Combined ET with taking 10 mg/kg atorvastatin significantly increased serum levels of IL-10 (P=0.001), but the combined effect of ET and atorvastatin (5 and 15 mg/kg), ET alone and three doses of atorvastatin alone (5, 10 and 15 mg/kg) was not significant.

Conclusion: It seems that combined endurance training with taking 10 mg/kg atorvastatin is the best combination that can improve the inflammatory condition after MI.

Author Biographies

  • Akbar Azamian Jazi1, 1- Dept. of Physical Education & Sports Sciences, Faculty of Letters and Humanities, Shahrekord University, Shahrekord, Iran.
    عضو هیئت علمی گروه فیزیولوژی ورزشی، دانشیار
  • Iraj Ahmadi2, 2- Dept. of Physical Education & Sports Sciences, Faculty of Letters and Humanities, Shahrekord University, Shahrekord, Iran.
    گروه فیزیولوژی ورزشی،  دانشجوی کارشناسی ارشد فیزیولوژی ورزشی 
  • Ali Shafizadeh3, 3- Dept. of Physical Education & Sports Sciences, Faculty of Letters and Humanities, Shahrekord University, Shahrekord, Iran.
    عضو هیئت علمی گروه تربیت بدنی و علوم ورزشی، استادیار 
  • Mohammad Reza Hafezi4, 4. Dept. of Pathobiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
    عضو هیئت علمی گروه پاتوبیولوژی، دانشیار

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Published

2017-02-05

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Section

Original Article(s)

How to Cite

The Combined Effect of Endurance Training and Atorvastatin on Serum Interleukin-10 Levels Following Experimental Myocardial Infarction in Rats. (2017). Knowledge and Health in Basic Medical Sciences, 11(4), page:30-38. https://doi.org/10.22100/jkh.v11i4.1532

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