Evaluation of the Relationship between IL4 Gene Polymorphisms (rs2227284 and rs2243250) and the Risk of Prostate Cancer in Iranian Men

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https://doi.org/10.22100/jkh.v17i1.2690

Abstract

Introduction: Inflammation in tissues is one of the factors associated with cancer. Interleukins secreted by helper T cells such as IL4 with a dual role can be effective in cancer. In this study, the relationship between rs2227284 (-33T / G) and rs2243250 (-589C / T) polymorphisms of the interleukin IL4 gene and the risk of prostate cancer was investigated.

Methods: 100 blood samples from patients with prostate cancer and 100 samples from healthy individuals in the same age range were selected after approval by a specialist. The DNA of the samples was extracted by salting out method and their purity was confirmed by spectrophotometer and gel. Then, the polymorphisms in the gene were examined using RFLP-PCR technique. The results were analyzed using SPSS software version 21 with chi-square and logistic regression tests.

Results: CC mutant genotype in rs2227284 polymorphism showed a significant relationship between cancer and healthy groups. (P.V: 0.001, OR: 2.976, CI95%: 1.569-5.644). Also, both this polymorphisms with age over 60 years, body mass index above 25 had a statistically significant relationship but did not show a relationship with smoking. None of the polymorphisms were associated with cancer stage and Gleason score.

Conclusion: The rs2227284 polymorphism was associated with a higher risk of prostate cancer, and both polymorphisms were significantly associated with prostate cancer in those over 60 years of age and those with a higher body mass index. Confirmation of this requires further studies in a larger population.

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2022-03-16

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How to Cite

Evaluation of the Relationship between IL4 Gene Polymorphisms (rs2227284 and rs2243250) and the Risk of Prostate Cancer in Iranian Men. (2022). Knowledge and Health in Basic Medical Sciences, 17(1), Page:39-47. https://doi.org/10.22100/jkh.v17i1.2690

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