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Candidemia in Burn Patients: Epidemiology and Molecular Typing of Candida Isolates

Authors

  • Seyed Reza Aghili - Invasive Fungi Research Center, Communicable Diseases Institute/, Mazandaran University of Medical Sciences, Sari, Iran. orcid https://orcid.org/0000-0001-9469-0054
  • Tahereh Shokohi - Dept. of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. orcid https://orcid.org/0000-0003-3094-8436
  • Bahram Salari - Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
  • Seyedeh Zahra Noorani Baladezaei - Antimicrobial Resistance Research Center, Dept. of Infectious Diseases, Mazandaran University of Medical Sciences, Sari, Iran. orcid https://orcid.org/0000-0002-4622-1699
  • Mostafa Roudbari - Dept. of Laboratory Medicine, Faculty of Allied Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
  • Leila Faeli - Dept. of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. orcid https://orcid.org/0000-0002-9479-0255
  • Iman Haghani - Invasive Fungi Research Center, Communicable Diseases Institute/, Mazandaran University of Medical Sciences, Sari, Iran. - Dept. of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. orcid https://orcid.org/0000-0001-9723-7618
  • Sabah Mayahi - Dept. of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. orcid https://orcid.org/0000-0002-9264-8984

DOI:

https://doi.org/10.22100/jkh.v19i2.3106

Keywords:

Candidiasis, Candidemia, Burn, Species identification, Molecular method

Abstract

Introduction: Candidemia is a major hospital-acquired fungal infection, especially among burn patients. Recognizing the risk factors and the particular organism involved is crucial for effective treatment.

Methods: Blood samples from 147 hospitalized burn patients were collected, totaling 534 samples, and cultured in a biphasic medium, then incubated aerobically at 37°C. Candida species were identified using specialized culture media and RFLP-PCR with the MspI restriction enzyme. Descriptive statistics were applied to outline the risk factors, while Student's t-test was employed to compare the variables.

Results: Candidemia was detected in 8 patients (5.44%) among hospitalized burn patients. The mean age was 38.3±21.3 years, with an average hospital stay of 32.7 days, a total body surface area burned of 32.7%, and a mortality rate of 19.7%. Patients with candidemia had higher values for these variables. 

Conclusion: The rapid identification, effective management, and treatment of this infection can significantly decrease complications and mortality rates in patients with burn injuries.

 

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Published

2024-08-26

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Original Article(s)

How to Cite

Candidemia in Burn Patients: Epidemiology and Molecular Typing of Candida Isolates. (2024). Knowledge and Health in Basic Medical Sciences, 19(2), page:21-30. https://doi.org/10.22100/jkh.v19i2.3106

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