The Effect of Eight Weeks of Aerobic Exercise and Consumption of Cinnamon Powder on Mrna Abca1 Expression in Pbmc Cells and Apolipoproteins of Middle-Aged Postmenopausal Women

Abstract

Introduction: Atherosclerosis is one of the most important causes of death in the world and menopause due to decreased ovarian activity and estrogen secretion, fat accumulation leads to an increased risk of heart disease. Increased expression of ABCA1 and APO-A1 reduces atherosclerosis. The aim of this study was to evaluate the effect of eight weeks of aerobic exercise and cinnamon powder on ABCA1 expression in PBMC cells and apolipoproteins in postmenopausal women.

Methods: This study was performed on 60 postmenopausal women who were randomly divided into four groups. The first control group, the second group was eight weeks of aerobic exercise with cinnamon powder, the third group had eight weeks of cinnamon powder and the fourth group had eight weeks of aerobic exercise. Then, before and after the intervention, 10 cc blood samples were taken from all subjects and lymphocytes were isolated by centrifugation and MRNA purification was performed by PCR and the information obtained by covariance tests was significant (P≤0.05). Bonferroni follow-up was used to examine the differences between groups and analyzed in SPSS19 medium.

Results: Results showed that aerobic exercise, combination of aerobic exercise and cinnamon powder had a significant effect on the expression of ABCA1 genes, HDL, LDL and APO-A1. Cinnamon consumption also had a significant effect on ABCA1 and HDL expression, while no significant changes were observed on APO-A1 and LDL (P≤0.05).

Conclusion: Based on the research findings, it can be concluded that aerobic exercise and combination of aerobic exercise with cinnamon powder improves reverse cholesterol transfer and prevention of atherosclerosis in postmenopausal women, but consumption of cinnamon powder alone needs further studies.