Etiology, Symptoms, Diagnosis and Risks Associated with Celiac Disease in Athletes and Sports Communities: A Review Article
Authors
- Ayad Bahadori Monfared - Dept. of Social Medicine and Health, School of Medicine, Shahid Beheshti University of MedicalSciences, Tehran, Iran.
- Sajjad Tavakoli - Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
-
Mohammad Rostami-Nejad
- Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
https://orcid.org/0000-0003-2495-1831
-
Mahmood Khodadoost
- Dept. of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
https://orcid.org/0000-0002-0432-1042
-
Mostafa Rezaei-Tavirani
- استاد، مرکز تحقیقات پروتئومیکس، دانشکده پیراپزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.
https://orcid.org/0000-0002-5284-3179
DOI:
https://doi.org/10.22100/jkh.v19i3.3358Keywords:
Celiac disease, Anemia, Gluten, Athlete, Diet, Sports teamsAbstract
Celiac disease is an autoimmune enteropathy caused by gluten consumption in genetically predisposed individuals. Gluten is an alcohol-soluble protein found in grains such as wheat, barley, and ry. This abnormal response to gluten causes atrophy of the intestinal mucosa, which is associated with a decrease in the absorption capacity of the intestine and non-absorption of necessary substances and digestive and non-digestive symptoms.
Due to the increasing prevalence of celiac disease, it is crucial for athletes to have a comprehensive understanding of the disease, associated risks, and the management options of this disease in areas such as diet management and exercise prescription.
This review paper discusses the etiology of the disease, nutritional assessment, and exercise management for athletes with celiac disease.
References
Rostami Nejad M, Karkhane M, Marzban A, Nazemalhosseini Mojarad E, Rostami K. Gluten related disorders. Gastroenterol Hepatol Bed Bench. 2012 Winter;5(Suppl 1):S1-7.
Asgari F, Khodadoust M, Nikzamir A, Jahani-Sherafat S, Rezaei Tavirani M, Rostami-Nejad M. The role of tryptophan metabolism and tolerogenic dendritic cells in maintaining immune tolerance: Insights into celiac disease pathogenesis. Immun Inflamm Dis 2024;12(8):e1354.
Ravikumara M, Tuthill DP, Jenkins HR. The changing clinical presentation of coeliac disease. Arch Dis Child 2006;91:969–971.
Wagner G, Zeiler M, Berger G, Huber WD, Favaro A, Santonastaso P, et al. Eating Disorders in Adolescents with Celiac Disease: Influence of Personality Characteristics and Coping. Eur Eat Disord Rev. 2015 Sep;23(5):361-70.
Trynka G, Wijmenga C, van Heel DA. A genetic perspective on coeliac disease. Trends Mol Med 2010;16:537–550.
Romanos J, van Diemen CC, Nolte IM, Trynka G, Zhernakova A, Fu J, et al. Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease. Gastroenterology 2009;137:834–840, 840.e1-3.
Dieli-Crimi R, Cénit MC, Núñez C. The genetics of celiac disease: A comprehensive review of clinical implications. J Autoimmun 2015;64:26–41.
Parzanese I, Qehajaj D, Patrinicola F, Aralica M, Chiriva-Internati M, Stifter S, Elli L, Grizzi F. Celiac disease: From pathophysiology to treatment. World J Gastrointest Pathophysiol. 2017;8(2):27-38.
Harper JW, Holleran SF. Anemia in celiac disease is multifactorial in etiology. Am J Hematol 2007;82:996–1000.
Rubio-Tapia A, Ludvigsson JF, Brantner TL, Murray JA, Everhart JE. The prevalence of celiac disease in the United States. Am J Gastroenterol 2012;107:1538–1544.
Van der Windt DAA, Jellema P, Mulder CJ, Kneepkens CM, van der Horst HEE. Diagnostic testing for celiac disease among patients with abdominal symptoms: A systematic review. JAMA 2010;303:1738–1746.
Motta M, Faria M, Silva G. Prevalence of low bone mineral density in children and adolescents with celiac disease under treatment. Sao Paulo Med J 2009;127:278–282.
Catassi C, Fasano A. Celiac disease diagnosis: Simple rules are better than complicated algorithms. Am J Med 2010;123:691–693.
Sabatino A, Corazza G. Coeliac disease. Lancet 2009;373:1480–1493.
Heyman R, Guggenbuhl P, Corbel A, Bridoux-Henno L, Tourtelier Y, Balencon-Morival M, et al. Effect of a gluten-free diet on bone mineral density in children with celiac disease. Gastro Clin Et Biol 2009;33:109–114.
Ertu¨ rk E, Wouters S, Imeraj L, Lampo A. Association of ADHD and celiac disease: What is the evidence? A systematic review of the literature. J Atten Disord 2020;24(10):1371-1376.
Hill ID, Dirks MH, Liptak GS, Colletti RB. Guideline for the diagnosis and treatment of celiac disease in children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Ped Gastro Nutr 2005;40:1–19.
Leone JE, Wise KA, Mullin EM, Gray KA, Szlosek PA, Griffin MF, Jordan CA. Celiac Disease Symptoms in Athletes: Prevalence Indicators of Perceived Quality of Life. Sports Health. 2020 May/Jun;12(3):246-255.
Leone JE, Gray KA, Massie JE. Celiac disease symptoms in a female collegiate tennis player: A case report. J Athl Train, 40: 365–369, 2005.
Noruzpour A, Gholam-Mostafaei FS, Looha MA, Dabiri H, Ahmadipour S, Rouhani P, Ciacci C, Rostami-Nejad M. Assessment of salivary microbiota profile as a potential diagnostic tool for pediatric celiac disease. Sci Rep 2024;14(1):16712.
McGowan KE, Castiglione DA, Butzner JD. The changing face of childhood celiac disease in North America: Impact of serological testing. Pediatrics 124: 1572–1578, 2009.
Bianchi MLL, Bardella MT. Bone in celiac disease. Osteoporos Int 19: 1705–1716, 2008.
Melton J, Atkinson E, O’Connor M, O’Fallon M, Riggs L. Bone density and fracture risk in men. J Bone Miner Res 13:1915–1923, 1998.
De Kam D, Smulders E, Weerdesteyn V, Smits-Engelsman BC. Exercise interventions to reduce fall-related fractures and their risk factors in individuals with low bone density: A systematic review of randomized controlled trials. Osteoporos Int 20: 2111–2125, 2009.
Eberman LE, Cleary MA. Celiac disease in an elite female collegiate volleyball athlete: A case report. J Athl Train 40:360–364, 2005.
Jahdkaran M, Asri N, Esmaily H, Rostami-Nejad M. Potential of nutraceuticals in celiac disease. Tissue Barriers. 2024 Jun 30:2374628. doi: 10.1080/21688370.2024.2374628.
Asri N, Rostami-Nejad M, Rezaei-Tavirani M, Razzaghi M, Asadzadeh-Aghdaei H, Zali MR. Novel Therapeutic Strategies for Celiac Disease. Middle East J Dig Dis. 2020 Oct;12(4):229-237. doi: 10.34172/mejdd.2020.187. PMID: 33564379; PMCID: PMC7859609.
Mancini LA, Trojian T, Mancini AC. Celiac disease and the athlete. Curr Sports Med Rep. 2011 Mar-Apr;10(2):105-8. doi: 10.1249/JSR.0b013e31820f2eab.
Martínez-Rodríguez A, Loaiza-Martínez DA, Sánchez-Sánchez J, Marcos-Pardo PJ, Prats S, Alacid F, Rubio-Arias JA. Tools Used to Measure the Physical State of Women with Celiac Disease: A Review with a Systematic Approach. Int J Environ Res Public Health. 2020 Jan 15;17(2):539. doi: 10.3390/ijerph17020539.
Lis DM. Exit Gluten-Free and Enter Low FODMAPs: A Novel Dietary Strategy to Reduce Gastrointestinal Symptoms in Athletes. Sports Med. 2019 Feb;49(Suppl 1):87-97. doi: 10.1007/s40279-018-01034-0.
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