The Comparison of Vitamin E and Fennel Extract Effects on Duration of Pain in Primary Dysmenorrheal
DOI:
https://doi.org/10.22100/jkh.v7i2.81Keywords:
Primary dysmenorrheal, Vitamin E, Fennel extractAbstract
Introduction: Primary dysmenorrheal is described as pelvic pain during menstrual bleeding in the absence of an identifiable pathologic lesion. It is a common gynecologic problem among women in reproductive age groups. Our objective was to compare the effect of vitamin E and Fennel extract on primary dysmenorrheal.
Methods: In this randomized single blind, placebo-controlled trial, 65 single female students who suffered from primary dysmenorrheal were randomly assigned into 3 groups of Fennel extract, vitamin E and placebo. Groups used treatment four times a day from the onset of bleeding and continued through three days for two consecutive menstrual periods. The vitamin E group took 100 unit capsules and Fennel extract group took 46 mg capsules with commercial name of Fenalgin.
Results: In the Fennel extract group, one month and two months after treatment, mean of pain duration significantly reduced compared to before treatment (P<0.001) but in the vitamin E group, the pain duration mean decreased only two months after treatment (P<0.02). The comparison of the first cycle means of pain duration, shows a significant difference between the three groups (P=0.033).
Conclusion: The results show that fennel extract is more effective than vitamin E in reducing the duration of pain in primary dysmenorrheal.
References
Irvani M. The effect zataria multiflora on primary dysmenorrhea. Journal of Herbal Drugs 2009;11(2):55-60.[Persian].
Daniels S, Robbins J, West CR, Nemeth MA. Celecoxib in the treatment primary dysmenorrhea: result from two randomized, double-blind, active and placebo- controlled crossover studies. Clinical Therapeutics 2009;31(6):1192-1208.
Modarsnezhad V, Motamedi B, Asadipoor M. The comparison fennel and mefenamic acid on dysmenorrhea. Journal of Rafsanjan University of Medical Sciences 2006;5(1):1-6.[Persian].
Nazarpoor S, Azimi H. The comparison fenelin and mefenamic acid on primary dysmenorrhea. Journal of Mazaandran University of Medical Sciences2007;17(61):54-61.[Persian].
Akhlaghi F, Zirak N, Nazemian SH. The effect vitamin E on primary dysmenorrhea. Journal of Hayat 2009;15(1):13-19.[Persian].
O Connell K, Davis A, Westhoff C. Self treatment patterns among adolescent girls with dysmenorrhea. Pediatr Adosc Gynecol Journal 2006;19:285-289.
Molazem Z, Alhani F, Anooshe M, Vagharseyyedin SA. Epidemiology of dysmenorrhea with dietary habits and exercise. Zahedan Journal of Research in Medical Sciences 2011;13(3):41-45.[Persian].
Kermanshahi S, Hosseinzadeh Sh, Elhani F. The effect of the group counseling program on the status dysmenorrhea, dietary condition and exercise on girls high school. Journal of Zanjan University of Medical Sciences 2008;16(65):49-60.[Persian].
Khodakarami N, Moatar F, Ghahari A, Soloki S. The effect of iranian herbal drug on primary dysmenorrea: A clinical controlled trial. J Midwifery & Women Health 2009;54(5):401-404
Nagata C, Hirokawa K, Shimizu N, Shimizu H. Associations of menstrual pain with intake of soy, fat and dietary fibr in Japanese women. European Journal of clinical Nutrition2005;59:88-92.
Azgeli G, Goli M, Moatar F, Valai N. The comparison zangebil, mefenamic acid and ibubrofen on dysmenorrhea. Journal of Shahid Beheshti University of Medical sciences and Health Services 2008;31(1):61-5.[Persian].
Farahmand M, Zahediasl S, Abaspoor Z, Rasekh A. The effect vitamin E and ibubrofen on mount duration and interval bleeding in dysmenorrheal women. Journal of Medicin Kosar 2009;14(1):49-52.[Persian].
Ziaei S, Zakeri M. Kazemnezhad A. A randomized controlled trial of vitamin E in treatment of primary dysmenorrhea. BJOG2004;112(4):466-9.
French l. Dysmenorrea. Am Fam physician 2005;71(2):285-91.
Decherney AH. Current obstetrics & gynecologic diagnosis & treatment. 9th ed. New York: Mc Grow-Hill;2003.
Ostad SN, Soodi M, Shariffzadeh M, Khorshidi N, Marzban H. The effect of Fennel essential oil on uterine contraction as a model for dysmenorreal, pharmacology and toxicology study. J Ethnopharmacol 2000;76:299-304.
Torkzahrai Sh, Akhavanamjadi M, Mojab F, Alavimajd H. The effect Foeniculum vulgare on primary dysmenorrhea. Journal of productive and infertility 2007:45-51.[Persian].
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