The Effects of 8 Weeks Resistance Training on Serum Myonectin and Insulin Resistance in Obese Women

Abstract

Introduction: Myonectin is one of the myokines and has gained interest as a potential new strategy to combat obesity and its associated metabolic disorders. The objective of this study was to investigate the effects of 8 weeks resistance training on serum myonectin and insulin resistance in obese women.

Methods: 24 obese women (31.3±2.32 kg/m²) were selected to participate in this semi-experimental study.They divided into experimental and control groups randomly. For 8 weeks, the experimental group performed resistance training with 3 sets of 8-10 repetitions in each exercise and the intensity of 50-85 percent of one repetition maximum. Rest time between sets and repetition were determined 2-3 minutes and 30-60 seconds, respectively. 48 hours before training and 48 hours after the last training session, blood samples were collected in the fasting state to measure myonectin and insulin resistance by ELISA and HOMA-IR formula. The data were analyzed at significant level of P≤0.05 using 23th version of SPSS software.

Results: According to the results, there were significant difference in serum levels of myonectin and insulin resistance after 8 weeks of resistance training (P=0.03, P=0.02 respectively).

Conclusion: Although it has been observed that exercise cause increase in myonectin and improve metabolic disorder, but it seems that  myonectin,s change mechanism in response to resistance training,  may be different in obese people and it may related to myonectin elevation in these people.