The Effect of Inositol on Fertility in Frozen Embryo Transfer Cycles in Poly Cystic Ovary Syndrome

Abstract

Introduction: The present study aimed to investigate the effect of inositol on endometrial receptivity and pregnancy rates in patients with polycystic ovary syndrome (PCOS) undergoing frozen embryo transfer (FET) cycles.

Methods: In this double-blind clinical trial, sixty patients with PCOS undergoing FET cycles were randomly assigned to two groups. The control group received 6 mg of estradiol tablets starting on the third day of the menstrual cycle, along with folic acid for eight weeks. The intervention group received the same estradiol regimen along with Inofolic for eight weeks. Embryo transfer was then performed using embryos of appropriate quality, and endometrial thickness (mm), biochemical pregnancy rate, clinical pregnancy rate, and spontaneous abortion rate were evaluated in both groups. A significance level of P≤0.05 was considered statistically significant.

Results: There were no significant differences between the intervention and control groups in terms of age (P=0.899), BMI (P=0.976), type of infertility (P=0.99), number of transferred embryos (P=0.894), biochemical pregnancy rate (P=0.99), clinical pregnancy rate (P=0.99), or spontaneous abortion rate (P=0.99). Although, myoinositol caused a significant increase in endometrial thickness (P=0.005).

Conclusion: Despite the significant positive effect of myoinositol on endometrial thickness in patients with PCOS, this increase did not influence biochemical pregnancy, clinical pregnancy, or miscarriage rates. This suggests that other factors, such as endometrial receptivity or embryo quality, may play a key role in implantation success.