Association Study of rs6929846 in BTN2A1 gene and CAD in an Iranian population

Authors

  • Mohamad Sadegh Yeganeh1 1- Dept. of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
  • Fateme Sadat Bitaraf2 2- کارشناس ارشد بیوتکنولوژی- گروه بیوتکنولوژی- دانشگاه علوم پزشکي شاهرود- شاهرود- ايران orcid http://orcid.org/0000-0002-5851-582X
  • Kamran Javidi aghdam3 3- Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Asghar Shayannia*4 4Dept. of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. orcid http://orcid.org/0000-0002-8837-4861

DOI:

https://doi.org/10.22100/jkh.v15i1.2396

Abstract

Introduction: Coronary heart disease is the leading cause of death worldwide. It is a complex multifactorial disorder influenced by both genetic and environmental factors. The aim of study was to determine the association of rs6929846 of BTN2A1 with the development of Coronary heart disease (CAD).

Methods: In the current case-control study, we genotyped rs6929846 single nucleotide polymorphisms (SNPs) in 150 CAD patients as well as in 150 healthy matched subjects by the TaqMan SNP Genotyping Assay.

Results: Genotype frequencies did not deviate from the Hardy–Weinberg equilibrium in the controls and cases (all P>0.05). There was no significant difference in allele and genotype frequency between the control and patient groups. (P>0.05)

Conclusion: This is the first study exploring an association between the BTN2A1 gene polymorphism and CAD risk in an Iranian population. Based on the results, no significant association was found between BTN2A1 gene polymorphism and CAD disease. Future studies with different populations and stronger power are required to confirm the findings of the study further.

Additional Files

Published

2020-07-12

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Section

Original Article(s)

How to Cite

Association Study of rs6929846 in BTN2A1 gene and CAD in an Iranian population. (2020). Knowledge and Health in Basic Medical Sciences, 15(1), Page:19-23. https://doi.org/10.22100/jkh.v15i1.2396

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